The invention discloses lactobacillus plantarum capable of adjusting ampicillin induced intestinal flora disturbance and belongs to the technical field of food. The lactobacillus plantarum CGMCC12436disclosed by the invention is amplification cultured under assistance of skimmed milk, trehalose and saccharose; after being frozen and dried, the lactobacillus plantarum is prepared into a biologicalpreparation; a viable bacterial content of the lactobacillus plantarum CGMCC12436 in the preparation is larger than 109CFU/g. The lactobacillus plantarum CGMCC12436 disclosed by the invention has theadvantages of lower growth generation time, high survival rate in in-vitro simulated gastric fluid and intestinal juice, good adhesion on human HT-29 cells and relatively lower drug resistance in drug allergy testing. The biological preparation prepared from the lactobacillus plantarum has the advantages that ampicillin induced intestinal flora disturbance in a mouse body can be obviously recovered, intestinal functions can be improved and has good market application prospect.