The invention discloses an antitumor drug nelarabine powder injection, and belongs to the technical field of medicine. The powder injection is composed of 1 part by weight of nelarabine and 0.1 to 0.3 part of anhydrous sodium carbonate; wherein the nelarabine is in a crystal form, and the X-ray powder diffraction pattern obtained through Cu-K alpha rays of the nelarabine crystal is represented by the picture 1. The provided novel nelarabine crystal is different from the conventional crystal forms. The test results show that the purity of the novel nelarabine crystal is high, the fluidity and water solubility are good, the stability is high, and the nelarabine crystal does not absorb water easily and is safe and reliable in clinic. The powder injection prepared from the novel nelarabine crystal has the advantages of high purity, low impurity content, and good clarity, moreover, the split charging efficiency is guaranteed during the production process, the weight difference between batches is little, the happening rate of adverse reactions is largely reduced, and the stability is improved.