The invention discloses a method for manufacturing an NbTi-CuNi-Cu superconductive composite wire rod. The method comprises the following steps of putting an NbTi alloy rod into a Cu tube, and obtaining an NbTi-Cu single-core composite rod blank through a hot extrusion or sleeve extension method; extending the NbTi-Cu single-core composite rod blank to a hexagonal rod to obtain an NbTi-Cu single-core composite rod, putting the NbTi-Cu single-core composite rod into a copper tube to manufacture an NbTi-Cu multi-core composite rod; putting the NbTi-Cu single-core composite rod or the NbTi-Cu multi-core composite rod into a copper tube, sleeving a CuNi tube with the copper tube, sleeving another copper tube with the CuNi tube, and sealing two ends of the copper tube; reducing space in the copper tube through a hot isostatic pressure method and performing hot extrusion to obtain an NbTi-CuNi-Cu composite rod; performing multiple cold extension and aging treatment on the NbTi-CuNi-Cu composite rod to obtain the superconductive composite wire rod with the required dimension and shape. By means of the method, alternating current loss of the NbTi superconductive composite wire rod is reduced, production processes are simplified, and production cost is reduced.