The invention relates to an anti-wear mixed flow water turbine capable of adapting to high head, high rotation speed and high sand content. The anti-wear mixed flow water turbine comprises a volute, afixed guide vane, a movable guide vane, a rotating wheel and a draft pipe. The movable guide vane molded lines are symmetrical two cubic curve assembly, which makes the velocity in the guide vane area and the resistance loss in the flow passage smaller and the flow more smoothly, and effectively reduces the wear of sediment to the guide vane outlet area; and the newly designed long and short vanerotating wheel can better match the flow field and the structural strength of the rotating wheel, and significantly reduce the wear of sediment to the outlet side of the rotating wheel. The thickness change rule of rotating wheel diameter, vane wrap setting angle, vane inlet angle and the vane from inlet to the outlet can be designed newly through the long and short vane rotating wheel, so thatthe flow field can be matched better, the structural strength of the rotating wheel is better, and the wear of the sediment to the outlet side of the rotating wheel.