The invention relates to a
glioblastoma multiforme targeting nano magnetic
resonance contrast agent as well as preparation and application thereof. The magnetic
resonance contrast agent consists of asmall molecule with a targeting combination function, a
fluorescence indicator and a magnetic
iron oxide nano carrier, wherein the
small molecule with the targeting combination function is
oligopeptide which has affinity with EGFRvIII which is highly expressed on the surface of a
glioblastoma multiforme
cell; the surface of the nano carrier is coated by the
fluorescence indicator in a covalent linkage manner; the
oligopeptide is connected with
polyethylene glycol on surfaces of nanoparticles in the covalent linkage manner. The contrast agent can be administrated in an intravenous injection manner, the
oligopeptide is combined with EGFRvIII which is highly expressed on the surface of a tumor
cell, concentrated accumulation of the nano carrier at a tumor part is promoted, clinical treatmentprecision and security can be improved, and a noninvasive visible means are provided for
treatment effect evaluation of tumor
chemoradiotherapy and prognosis evaluation on patients.