2 results about "Initial burst" patented technology

The invention relates to a tissue fiber bracket and a preparation method thereof, in particular to a fiber bracket containing growth factors and a preparation method thereof. The fiber bracket consists of composite fiber material and is manufactured by a coaxial electrospinning spinning device; and the composite fiber material consists of organic polymers with the weight-average molecular weight of 5-500000 and growth factors, and an organic polymer solution and a growth factor solution are mixed and then electrostatically spun to obtain the composite fiber material. The invention has the beneficial effects that the fiber bracket is prepared according to the method disclosed by the invention, the composite fiber material in a nanometer structure is prepared by the coaxial electrostatic spinning method, fiber in a nuclear shell structure can be prepared, the encapsulation rate of electrostatically spun fiber is improved, the initial burst release of the growth factors is slowed down, the bioactivity of the growth factors can be maintained for a long time, the method has a simple process and low cost, is easy to operate, and has wide application prospects in the fields of tissue engineering, wound dressing and the like.

The invention discloses a preparation method of bezoar ursodesoxycholic acid preparation. The preparation method of the bezoar ursodesoxycholic acid preparation comprises the following steps: sieving a bezoar ursodesoxycholic acid raw material and an auxiliary material for later use, wherein particle size distribution D90 of the raw material is required to be less than 150 microns, and the particle size distribution D90 of the auxiliary material is required to be less than 120 microns; mixing bezoar ursodesoxycholic acid, a diluent and a disintegrating agent, collecting a material accounting for about 10-15% of production lot size to be taken as (a) for later use; adding a lubricating agent accounting for 85-90% of the production lot size, mixing, and collecting material taken as (b) for later use; carrying out dry granulation on the material (b); straightening the material obtained in the step 3, sieving, mixing the sieved material with the material (a), carrying out dry granulation on the mixed material, and then straightening and sieving; adding the material obtained in the step 4 into the rest lubricating agent, mixing, and collecting a material; and preparing the preparation by adopting the material obtained in the step 5. The preparation method of the bezoar ursodesoxycholic acid preparation has the advantages that the problem of material fluidity can be solved and the phenomenon that no initial burst release of the bezoar ursodesoxycholic acid preparation is caused under the specified dissolution condition can be avoided.