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1 results about "Murine antibody" patented technology

Definition of murine antibodies. Antibodies, also called immunoglobulins, make up the main part of the specific endogenous defence. They are made by the immune system in response to substances which are foreign to the organism (antigens = antibody generating).

Anti-cd19 humanized antibody and immune effector cell targeting cd19

ActiveUS20200062843A1Peptide/protein ingredientsAntibody mimetics/scaffoldsAntiendomysial antibodiesMurine antibody
Disclosed are an anti-CD19 humanized antibody prepared from a murine monoclonal antibody, a chimeric antigen receptor containing the humanized antibody, and an immune cell expressing the humanized antibody. Not only does the humanized antibody of the present invention not produce an anti-antibody response (AAR) and a human anti-mouse antibody response (HAMA), but same also has better affinity than a murine antibody, and has excellent activity and safety, thereby providing a new means for treating CD19-expressing tumors.
Owner:CRAGE MEDICAL CO LTD
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