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1 results about "Murine monoclonal antibody" patented technology

Monoclonal antibodies with clinical indications. Definitions. Murine: A murine antibody is one of which both chain types are of mouse origin. A murine antibody is identified by the pre-stem -o- in its INN.

Anti-cd19 humanized antibody and immune effector cell targeting cd19

ActiveUS20200062843A1Peptide/protein ingredientsAntibody mimetics/scaffoldsAntiendomysial antibodiesMurine antibody
Disclosed are an anti-CD19 humanized antibody prepared from a murine monoclonal antibody, a chimeric antigen receptor containing the humanized antibody, and an immune cell expressing the humanized antibody. Not only does the humanized antibody of the present invention not produce an anti-antibody response (AAR) and a human anti-mouse antibody response (HAMA), but same also has better affinity than a murine antibody, and has excellent activity and safety, thereby providing a new means for treating CD19-expressing tumors.
Owner:CRAGE MEDICAL CO LTD

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