The invention discloses a catalyst-based chlorinated neopentane preparation technology which is characterized in that a addition reaction is carried out on isoamylene and 36% of hydrochloric acid (in mass percent) under the condition of zinc chloride, the molar ratio of the zinc chloride to the isoamylene is 3:500-6:500, the molar ratio of the isoamylene to hydrochloric acid is 1:1.1-1:1.3, the reaction temperature is 5+/-1 DEG C, and the reaction time is 4-5 hours. The catalyst-based chlorinated neopentane preparation technology has the beneficial effects of having simple technology, being convenient to prepare, easy to realize and short in reaction time, having less addition side reaction, high product content and yield, effectively solving the problem that high content pentane chloride cannot be produced if phosphorous acid is not coproduced, and being considerable in economic benefit.