Copper sodium chlorophyllate tablets and preparation method thereof
A technology of sodium copper chlorophyll and filler, which is applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve problems such as large differences in stability and limited sources of raw materials for extraction.
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Embodiment 1
[0011] Since sodium copper chlorophyllin comes from silkworm excrement or green plants, it may have a strong affinity with starch or cellulose. In order to verify the adsorption of excipients, the present invention uses water-insoluble and water-soluble fillers in different proportions to formulate the excipients. of adsorption.
[0012]
[0013] Conclusion: Prescription 1 and Prescription 3 use fully soluble excipients, and there is no excipient adsorption during the preparation process. Prescription 4 has half of the insoluble excipients, and the content is obviously higher than that in Prescription 2. The above shows that the adsorption of insoluble excipients is more serious, so the present invention uses fully soluble excipients.
Embodiment 2
[0015] In the prior art, the water content of sodium copper chlorophyllin particles is more than 6%, which is the main factor affecting the reduction of sodium copper chlorophyllin content. The present invention starts with reducing the water content of the product and tests. Therefore, absolute ethanol was used as the wetting agent in the following tests to minimize the interference of moisture. Due to the high correlation between moisture and compressibility in the prescription, some excipients with better compressibility were used as much as possible in the selection of excipients, and alcohol-soluble adhesives with strong viscosity were used.
[0016] Changes in Weight Gain of Copper Chlorophyllin Sodium
[0017]
[0018] Conclusion: In the case of a relative humidity of 90%, the moisture absorption weight gain is 1.97%, which shows that the moisture absorption capacity of this product is limited, and most of the content drop under high humidity conditions is due to degra
Embodiment 3
[0020] The test prescription 091201-2 has a sticking phenomenon. Therefore, domestic lactose was used to replace half of the sucrose as filling, and magnesium stearate with good lubricating properties was used instead of talcum powder as lubricant.
[0021] ①. Prescription composition (500 tablets):
[0022] components
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