Captopril zinc complexe and its preparation method and preparation

[0039] A preparation method of captopril zinc complex, comprising the steps of:

[0040] 1) Add excess captopril and zinc oxide or zinc hydroxide into water or an organic solvent according to the reaction formula, and fully stir;

[0041] 2) Filtrating the generated precipitate and drying under reduced pressure to obtain the captopril zinc complex.

[0042] Because the solubility of zinc oxide itself is extremely small, in order to make the reaction more complete and to make the impurities in the product easy to remove, captopril should be added in excess so that the molar weight of captopril is greater than that of zinc oxide . Preferably, the molar ratio of captopril to zinc oxide is (2-3):1.

[0043] In the above reaction, the organic solvent is preferably a polar organic solvent. Preferably, the organic solvent is miscible with water and can dissolve a certain amount of zinc oxide or zinc hydroxide. In particular, the organic solvent is selected from methanol, acetone, ace

[0056] Weigh 217 mg of captopril and 41 mg of zinc oxide, add 2 mL of methanol, stir and react at 60°C for 8 hours to obtain a white suspension, filter, and dry under reduced pressure to obtain 130 mg of a white powdery solid, with a yield of 93%.

[0058] Weigh 217 mg of captopril and 27 mg of zinc oxide, add 2 mL of water, stir and react at room temperature for 12 hours to obtain a white suspension, filter, and dry under reduced pressure to obtain 89 mg of a white powdery solid with a yield of 96%.