Micro-fluidic chip for preparing microspheres and using method of micro-fluidic chip

A microfluidic chip and chip technology, applied in the direction of microsphere preparation, chemical instruments and methods, microcapsule preparations, etc., can solve the problems of increased production cost, use cost, lack of microfluidic chips, difficulty in popularization and use, etc. , to achieve the effect of low cost of use, small particle size dispersion and strong professionalism

Active Publication Date: 2015-05-06
重庆新赛亚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This technology allows for easier operation but also provides better results compared to current techniques like crushing or sizing microparticles. It produces smaller particles that have higher precision when combined together without losing their shape during manufacturing process. Additionally it makes producing multiple types of materials efficiently at once while being less expensive.

Problems solved by technology

Technological Problem: Current methods for producing small spherules with nanoparticle composites require complicated processes that can be expensive and time-consuming. There needs an improved way to make these tiny objects quickly and easily without requiring specialized equipment like traditional gel techniques.

Method used

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  • Micro-fluidic chip for preparing microspheres and using method of micro-fluidic chip
  • Micro-fluidic chip for preparing microspheres and using method of micro-fluidic chip
  • Micro-fluidic chip for preparing microspheres and using method of micro-fluidic chip

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] refer to Figure 1 to Figure 5 The shape structure in , a microfluidic chip for preparing microspheres, has an injection hole A3, an injection hole B5 and an injection hole C7. The V-shaped opening angle of the V-shaped mixing pipe is 30°, and the side length is 3mm. All channels on the chip are 500 μm wide and 300 μm deep. The height of the cold water storage cavity 22 of the cooling chip 12 is 3mm; the thickness T=3mm above the cooling double U-shaped pipe 11, and the depth of the cooling pit 21 is t=2mm. On the surface of the volatilization exhaust chip 14, five air pipes 17 are processed and installed on both sides of the rectangle, and 100 volatilization exhaust holes 18 are processed side by side on the other surfaces; the height of the exhaust cavity 20 of the volatilization exhaust chip 14 is H=3mm , the height d of the exhaust pipe 19 of the shaped collection pool protruding from the surface of the chip body 1 = 1.5 mm.

[0024] During operation, prepare 1% pol

Embodiment 2

[0028] refer to Figure 1 to Figure 5 The shape structure in , a microfluidic chip for preparing microspheres, the V-shaped opening angle of the V-shaped mixing channel is 60°, and the side length is 5mm. All channels on the chip are 100 μm wide and 100 μm deep. The height of the cold water storage cavity 22 of the cooling chip 12 is 2 mm; the thickness T=2 mm above the cooling double U-shaped pipe 11, and the depth of the cooling pit 21 is t=1 mm. On the surface of the volatilization exhaust chip 14, 10 ventilation pipes 17 are processed and installed on both sides of the rectangle, and 50 volatilization exhaust holes 18 are processed side by side on the other surfaces; the height of the exhaust cavity 20 of the volatilization exhaust chip 14 is H=2mm , the height of the exhaust pipe 19 of the shaped collection pool protruding from the surface of the chip body 1 is d = 1 mm.

[0029] The operation method is according to the first embodiment, and the round microspheres are obtain

Embodiment 3

[0031] refer to Figure 2 to Figure 6 The shape structure in , a microfluidic chip for preparing microspheres, has an injection hole A 3 , an injection hole B 5 , an injection hole D and an injection hole C 7 . The V-shaped opening angle of the V-shaped mixing pipe is 45°, and the side length is 4mm. All channels on the chip are 80 μm wide and 50 μm deep. The height of the cold water storage cavity 22 of the cooling chip 12 is 4 mm; the thickness T above the cooling double U-shaped pipe 11 is 4 mm, and the depth of the cooling pit 21 is t = 3 mm. On the surface of the volatilization exhaust chip 14, eight air pipes 17 are processed and installed on both sides of the rectangle, and 25 volatilization exhaust holes 18 are processed side by side on the other surfaces; the height of the exhaust cavity 20 of the volatilization exhaust chip 14 is H=4mm , the height of the exhaust pipe 19 of the shaped collection pool protruding from the surface of the chip body 1 is d = 2 mm.

[0032

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Abstract

The invention provides a micro-fluidic chip for preparing microspheres and a using method of the micro-fluidic chip. The micro-fluidic chip is mainly compounded by a chip body, a cooling chip and a volatilizing and exhausting chip. The micro-fluidic chip is characterized by comprising two V-shaped mixing pipelines I and II which are integrally U-shaped, circular cooling double U-shaped pipelines, a sizing and collecting pond which is arranged on one side of the circular cooling double U-shaped pipelines, an outlet and the like. The invention further provides a using and operating method of the chip. The micro-fluidic chip provided by the invention has the beneficial effects that the prepared microspheres are small in particle size dispersity and high in dimensional precision, compound microspheres with more than two components can be quickly prepared, the production efficiency is high and the operation is convenient and simple.

Description

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Claims

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Application Information

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Owner 重庆新赛亚生物科技有限公司
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