Targeted probe for photodynamic therapy and preparation method of targeted probe for photodynamic therapy

A photodynamic therapy and targeting technology, applied in the fields of photoacoustic imaging, fluorescence imaging, and ultrasound imaging, can solve the problems of poor water solubility, singleness, and poor tumor cell selectivity, and achieve strong tissue penetration, high targeting, and specific effect

Inactive Publication Date: 2016-08-24
INST OF AUTOMATION CHINESE ACAD OF SCI
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Benefits of technology

This patented technology describes how certain types of molecules called probes have been found useful both as agents for diagnostics (ultrasounds) and drugs for treatments like chemotherapies. They were developed by combining two different methods: they could use them either alone or together - making it easier than current techniques such as phthalocyanine blue injection. These new tools provide better accuracy at detecting cancer cells compared to other conventional approaches.

Problems solved by technology

This patents describes different types of photoimmunotherapies called opto-thermolysis or thermobiomics. These involve exposure to light energy to activate molecular targets inside tumor areas while minimizing harmful effects on healthy surrounding tissues like bacteria. However, current materials suffer from poor water solvability due to slow diffusion rates and limited sensitivity towards tumoral cells. To improve upon those drawbacks, we developed novel chemical entities containing both hydrogen atoms and nitrogens instead of traditional organism metabolites found naturally occurring during natural processes.

Method used

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  • Targeted probe for photodynamic therapy and preparation method of targeted probe for photodynamic therapy

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Embodiment Construction

[0015] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with specific embodiments and with reference to the accompanying drawings.

[0016] Such as figure 1 As shown, the present invention proposes a targeted probe capable of ultrasonic photoacoustic and fluorescence imaging for photodynamic therapy, including drug-loaded microbubbles and a photosensitizer wrapped inside the drug-loaded microbubbles. Targeting molecules are attached to the shell.

[0017] The photosensitizer is a photosensitizer with a photoacoustic signal. Wherein, in a preferred embodiment, the photosensitizer is ZnPc (zinc phthalocyanine); in another embodiment, the targeting molecule is LHRH (gonadotropin-releasing hormone).

[0018] Gonadotropin-releasing hormone (GnRH, amino acid sequence: EHWSYGLRPG), also known as luteinizing-hormone-releasing hormone (LHRH), is a neuron control

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Abstract

The invention discloses a targeting probe for photodynamic therapy and a preparation method. The targeting probe includes a synthetic drug-loaded microbubble, a targeting molecule small peptide LHRH (gonadotropin-releasing hormone) connected to it, and a photosensitizer ZnPc (zinc phthalocyanine) wrapped in it. Compared with the traditional photosensitizers, the present invention overcomes the disadvantages of the existing photosensitizers, which are non-targeting, difficult to be enriched to reach an effective concentration, easy to agglomerate, difficult to deliver to the tumor site, and mostly limited to the tumor site in the epidermis or superficial tissue area, providing A targeted multimode probe with ultrasonic signal, photoacoustic signal and fluorescent signal for photodynamic therapy with high targeting, strong tissue penetration, good stability and strong specificity.

Description

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Claims

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Application Information

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Owner INST OF AUTOMATION CHINESE ACAD OF SCI
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