Carbon-nitrogen material loaded cobalt catalyst and method for synthesizing pimavanserin intermediate

[0019] The synthesis of embodiment 1 catalyst A

[0020] Weigh 0.249g of cobalt acetate tetrahydrate in a round bottom flask, 30ml of methanol as a solvent, then add 0.472g of IL1 (the molar ratio of metal cobalt compound to IL1 is 1:3), stir at room temperature for 30min, then slowly add 1.0g of activated carbon (Based on a Co loading of 6% by mass). Put the round-bottomed flask into an oil bath at 50° C. and heat and stir for 5 h, then remove the solvent methanol by rotary evaporation. The obtained supported pre-catalyst was vacuum-dried at 60° C. for 12 hours. The dried pre-catalyst was placed in a tube furnace and calcined at 800°C for 2h under nitrogen (heating rate 5°C / min). After naturally lowering to constant temperature, catalyst A was obtained.

[0021] The synthesis of embodiment 2 catalyst B

[0022] Weigh 0.249g of cobalt acetate tetrahydrate in a round bottom flask, 30ml of methanol as a solvent, then add 0.547g of IL2 (the molar ratio of metal cobalt compound to IL2 is 1:3), stir at room temperature for 30min, then slowly add 1.0g of activated carbon (Based on a Co loading of 6% by mass). Put the round-bottomed flask in an oil bath at 55° C. and heat and stir for 5 h, then remove the solvent methanol by rotary evaporation. The obtained supported pre-catalyst was vacuum-dried at 60° C. for 12 hours. The dried pre-catalyst was placed in a tube furnace and calcined at 800°C for 2h under nitrogen (heating rate 5°C / min). After naturally lowering to a constant temperature, catalyst B was obtained.

[0023] The synthesis of embodiment 3 catalyst C

[0024] Weigh 0.249g of cobalt acetate tetrahydrate in a round bottom flask, 30ml of methanol as a solvent, then add 0.508g of IL3 (the molar ratio of metal cobalt compound to IL3 is 1:3), stir at room temperature for 30min, then slowly add 1.0g of activated carbon (Based on a Co loading of 6% by mass). Put the round-bottomed flask into an oil bath at 50° C. and heat and stir for 6 h, then remove the solvent methanol by rotary evaporation. The obtained supported pre-catalyst was vacuum-dried at 60° C. for 12 hours. The dried pre-catalyst was placed in a tube furnace and calcined at 800°C for 2h under nitrogen (heating rate 5°C / min). After naturally lowering to a constant temperature, catalyst C was obtained.