Preparation method of 3,5-di-tert-butyl-4-hydroxybenzyl alcohol

[0018] Synthesis of 3,5-di-tert-butyl-4-hydroxybenzaldehyde

[0019] Take 2.42mL POCl 3 (0.026mol) was added to 2.01mL DMF (0.026mol) at 0°C, stirred until a white solid was produced, and dissolved in 20mL 1,2-dichloroethane to obtain solution A. Dissolve 4.12g of 2,6-di-tert-butylphenol (0.02mol) in 20mL of 1,2-dichloroethane to obtain solution B. Add solution B dropwise to solution A at room temperature, reflux at 70°C for 2 hours, add saturated Na 2 CO 3 The solution was neutralized until no gas was produced, then refluxed at 80°C for 40 minutes, separated, the organic phase was washed with water, and Na 2 CO 3 Wash with saturated solution and dry. The organic phase was distilled off under reduced pressure to obtain 4.48 g of light brown flaky solid with a yield of 96% and a melting point of 185-189°C (literature value 186-190°C);

[0020] Synthesis of 3,5-di-tert-butyl-4-hydroxybenzyl alcohol

[0021] Take 4 g of 3,5-di-tert-butyl-4-hydroxybenzaldehyde (0.017 mol) prep