Pharmaceutical composition for treating Alzheimer's disease by combination of Chinese and Western medicines and preparation method of pharmaceutical composition

A combined treatment and composition technology, applied in the field of medicine, can solve the problems of inability to delay disease development, liver and kidney toxicity of western medicine, and insignificant curative effect, and achieve the effects of low side effects, broad medical application prospects, and short course of treatment.

Inactive Publication Date: 2018-01-30
余必亚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many western medicines for the treatment of Alzheimer's disease. These medicines can only temporarily alleviate the cognitive decline of patients, but cannot delay the development of the disease. Moreover, western medicines have serious adverse reactions such as liver and kidney toxicity, and are expensive.
In recent years, experts and scholars at hom

Method used

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  • Pharmaceutical composition for treating Alzheimer's disease by combination of Chinese and Western medicines and preparation method of pharmaceutical composition
  • Pharmaceutical composition for treating Alzheimer's disease by combination of Chinese and Western medicines and preparation method of pharmaceutical composition

Examples

Experimental program
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Effect test

Embodiment 1

[0020] A preparation method of a pharmaceutical composition for treating Alzheimer's disease in combination with Chinese and western medicine, comprising the steps of:

[0021] S1: Make 20 parts of Poria cocos, 10 parts of lavender, 10 parts of white peony, 12 parts of Shichangpu, 12 parts of hemp seed, 12 parts of Acanthopanax, and 12 parts of buffalo horn, add water to decoct 3 times, and filter , combine the filtrates, concentrate the filtrates under reduced pressure to 3 times the amount of raw materials, add ethanol with a mass concentration of 60-70%, stand still for 24-48h, remove the supernatant, concentrate and dry the precipitate under reduced pressure, and pulverize into fine powder for later use;

[0022] S2: Grinding 1.4 parts of nimodipine and 1.5 parts of piracetam into fine powder 2;

[0023] S3: Mix the fine powder 2 obtained in step S2 with the fine powder 1 obtained in step S1, add sodium carboxymethyl starch, dextrin, and magnesium stearate, mix evenly, granul

Embodiment 2

[0025] A preparation method of a pharmaceutical composition for treating Alzheimer's disease in combination with Chinese and western medicine, comprising the steps of:

[0026] S1: Make 25 parts of Poria cocos, 15 parts of lavender, 15 parts of white peony, 14 parts of Shichangpu, 14 parts of hemp seed, 14 parts of Acanthopanax, and 13 parts of buffalo horn, add water to decoct 3 times, and filter , combine the filtrates, concentrate the filtrates under reduced pressure to 3 times the amount of raw materials, add ethanol with a mass concentration of 60-70%, stand still for 24-48h, remove the supernatant, concentrate and dry the precipitate under reduced pressure, and pulverize into fine powder for later use;

[0027] S2: Grinding 2 parts of nimodipine and 2.5 parts of piracetam into fine powder 2;

[0028] S3: Mix the fine powder 2 obtained in step S2 with the fine powder 1 obtained in step S1, add sodium carboxymethyl starch, dextrin, and magnesium stearate, mix evenly, granulat

Embodiment 3

[0030] A preparation method of a pharmaceutical composition for treating Alzheimer's disease in combination with Chinese and western medicine, comprising the steps of:

[0031] S1: Make 30 parts of Poria cocos, 20 parts of lavender, 20 parts of white peony, 15 parts of Shichangpu, 15 parts of hemp seed, 15 parts of Acanthopanax, and 15 parts of buffalo horn, add water to decoct 3 times, and filter , combine the filtrates, concentrate the filtrates under reduced pressure to 3 times the amount of raw materials, add ethanol with a mass concentration of 60-70%, stand still for 24-48h, remove the supernatant, concentrate and dry the precipitate under reduced pressure, and pulverize into fine powder for later use;

[0032] S2: Grinding 3.2 parts of nimodipine and 3.5 parts of piracetam into fine powder 2;

[0033] S3: Mix the fine powder 2 obtained in step S2 with the fine powder 1 obtained in step S1, add sodium carboxymethyl starch, dextrin, and magnesium stearate, mix evenly, granul

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Abstract

The invention provides a pharmaceutical composition for treating an Alzheimer's disease by combination of Chinese and Western medicines and a preparation method of the pharmaceutical composition. Thepharmaceutical composition is prepared from a Chinese medicine component and a Western medicine component, wherein the Chinese medicine component is prepared from the following crude drugs in parts byweight: 20 to 30 parts of poria cocos, 10 to 20 parts of lavender, 10 to 20 parts of white paeony root, 12 to 15 parts of rhizoma acori tatarinowii, 12 to 15 parts of fructus cannabis, 12 to 15 partsof radix acanthopanacis senticosi and 12 to 15 parts of cornu bubali; the Western medicine component is prepared from the following crude drugs: 1.4 to 3.2 parts of nimodipine and 1.5 to 3.5 parts ofpiracetam. According to the pharmaceutical composition provided by the invention, a Chinese and Western medicine combining method is adopted, and various Chinese herbal medicines and Western medicines are finely selected and are combined to be mutually cooperated, so that the treatment effect on the Alzheimer's disease is enhanced; the pharmaceutical composition has the effects of tranquilizing by nourishing the heart, soothing liver-qi stagnation, eliminating dampness and eliminating phlegm, and enhancing the memory and the cognitive ability; the pharmaceutical composition can be used for effectively treating the Alzheimer's disease, has the advantages of short treatment course, rapid effect and low side effect and has a wide medical application prospect.

Description

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Claims

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Application Information

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Owner 余必亚
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