Diphenylheptane compound and its preparation method and application

A technology for diphenylheptane and compounds, which is applied to the field of diphenylheptane compounds and their preparation, can solve the problems of poor water solubility, complicated preparation methods, poor activity and the like, and achieves simple synthesis process, simple structure, and biological Activity enhancing effect

Active Publication Date: 2021-07-20
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Although the patents CN105732379A and CN105732380A disclose two diphenylheptane compounds and they can be used to prepare medicines or foods for preventing and treating psoriasis,

Method used

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  • Diphenylheptane compound and its preparation method and application
  • Diphenylheptane compound and its preparation method and application
  • Diphenylheptane compound and its preparation method and application

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[0076] The present invention will be further described in detail below with reference to the accompanying drawings.

[0077] 1, preparation of diphenhenheptane compounds

[0078] Accurately weighed 1,7-di (4-phenyl) heptyl-3,5-glycol ester 100 mg, accurately weighted cyclopropyl chloride 77.65 mg, triethylamine 40.30 mg, 5 mL of dichloromethane as a solvent . After 24 hours of reaction, the dichloromethane solution was dried to give 87.62 mg of a pale yellow viscous thick product. The co-drying pale yellow powder dried column was first eluted with petroleum ether: ethyl acetate (5: 1) 100 mL, the eluate was collected, and the product 1 was obtained, and the weight was 16.2 mg. Continue with petroleum ether: EtOAc EtOAc EtOAc EtOAc EtOAc EtOAc EtOAc EtOAc EtOAc EtOAc EtOAc.

[0079] After analysis, the product 1 is compound 1, and the product 2 is compound 2. Among them, the high resolution LC-MS spectrum of Compound 1 is like figure 1 As shown, [m + Na] of Compound 1 in the figure +

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Abstract

The present invention relates to the technical field of compound synthesis, in particular to diphenylheptane compounds and applications thereof, the structural formula of which is as follows: wherein, R 1 , R 2 Both are cyclopropanecarbonyl; or R 1 for H, R 2 is cyclopropanecarbonyl; or R 1 for H, R 2 is m-chlorobenzoyl; or R 1 for H, R 2 is or R1, R2 are both or R 1 for H, R 2 for R 3 is one of F, Br, trifluoromethyl or tert-butyl; or R 1 , R 2 Both are R 3 For acetamide. The compound of the present invention has biological activity of psoriasis, and has therapeutic effect on some immunosuppressive diseases. The compounds of the present invention are prepared into various pharmaceutically acceptable forms, such as tablets, pills, capsules, injections, suspensions or emulsions, which are expected to replace part of the existing drugs for treating psoriasis in the future.

Description

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Claims

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Application Information

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Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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