3D printing tissue engineering scaffold and preparation method thereof

A tissue engineering scaffold and 3D printing technology, applied in 3D printing, metal processing equipment, additive manufacturing, etc., can solve the problems of difficult loading of growth factors, difficulty in one-time molding of hydrogel materials and medical polymer materials, etc., and achieve mechanical good performance effect

Active Publication Date: 2019-02-15
深圳市晶莱新材料科技有限公司
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  • Abstract
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  • Claims
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Problems solved by technology

[0004] However, the current porous scaffolds based on selective laser sintering technology are difficult to load growth factors, and it is difficult to realize the one-time molding of hydrogel materials and medical polymer materials, as well as the slow release of growth factors and hydrogels.

Method used

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  • 3D printing tissue engineering scaffold and preparation method thereof
  • 3D printing tissue engineering scaffold and preparation method thereof

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Example Embodiment

[0023] The present invention also provides a preparation method of the claimed 3D printing tissue engineering scaffold, which includes the following steps:

[0024] S1: Preparation of artificial medical polymer-hydrogel composite microspheres series with gradient content of calcium and phosphorus active biomaterials: Synthesize hydrogel microspheres containing KGN, and wrap different contents of calcium and phosphorus on the outside of the hydrogel microspheres Active biological materials and artificial medical polymer materials to obtain artificial medical polymer-hydrogel composite microspheres;

[0025] S2: Design a three-dimensional model of the porous multi-level structure through software modeling;

[0026] S3: Using the selective laser sintering rapid prototyping technology, the series of artificial medical polymer-hydrogel composite microspheres are sintered layer by layer according to the model to obtain a porous laminate with a layer-by-layer gradient change in the cont

Example Embodiment

[0036] Example

[0037] S1: Preparation of a series of artificial medical polymer-hydrogel composite microspheres with gradient changes in the content of calcium and phosphorus active biomaterials. The series of artificial medical polymer-hydrogel composite microspheres refers to the artificial medical polymer-hydrogel composite microspheres corresponding to different layers in the porous laminated structure. In this embodiment, the porous laminated structure is preferably configured to include three layers, namely a shallow layer, a transition layer and a bottom layer. The artificial medical polymer-hydrogel composite microsphere series includes a shallow layer of artificial medical polymer-hydrogel composite microspheres, a transition layer of artificial medical polymer-hydrogel composite microspheres and a bottom layer of artificial medical polymer-hydrogel composite microspheres. Gel composite microspheres.

[0038] First prepare the shallow artificial medical polymer-hydro

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Abstract

The invention discloses a 3D printing tissue engineering scaffold and a preparation method thereof. The 3D printing tissue engineering scaffold is a porous laminated structure obtained by sintering, layer by layer, an artificial polymer-hydrogel composite micro ball which contains a calcium and phosphorus active biological material, the content of which changes in a gradient mode, according to a designed three-dimensional model by using a selective laser sintering rapid prototyping technology. The hydrogel composite micro ball is a hydrogel micro ball containing KGN, which is wrapped with an artificial medical polymer material and a calcium and phosphorus active biological material, or a hydrogel micro ball containing KGN, which is wrapped with an artificial medical polymer material. According to the 3D printing tissue engineering scaffold, the KGN is wrapped in the hydrogel micro ball and a calcium phosphate active biological material and an artificial polymer material are wrapped onthe surface of the hydrogel micro ball, through slow degradation of the surface artificial polymer material and hydrogel, the slow release of the KGN in a human body can be achieved, so that the repair of bone and cartilage tissue can be controlled.

Description

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Claims

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Application Information

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Owner 深圳市晶莱新材料科技有限公司
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