Method and system for determining protein similarity and similar protein

[0033] This embodiment provides a method for determining protein similarity, through protein spatial structure similarity, total atom number similarity, amino acid number similarity, amino acid type similarity, carbon atom number similarity, nitrogen atom number similarity, The similarity of the number of oxygen atoms, the similarity of P position, the similarity of S position and the path of α-carbon atoms at different elevation angles determine the similarity of proteins, thereby improving the accuracy of protein similarity calculation results.

[0034] The process flow of the protein similarity determination method provided by this embodiment is as follows: figure 1 shown, including the following steps:

[0035] (1) Establish a coordinate system, calculate the Mahalanobis distance between each atom in the two proteins and the origin, and layer the proteins according to the calculated Mahalanobis distance.

[0036] Unify the Markov coordinates into spatial coordinates with the

[0094] This embodiment provides a method for determining similar proteins, comprising the following steps:

[0095] (1) Obtain protein codes and download PDB files through the PDB database, search their amino acid sequences through NCBI, and obtain protein sequences and secondary structure diagrams through secondary database searches;

[0096] (2) Perform BLASTP (Basic Local Alignment Search Tool) search on the obtained amino acid sequence to find proteins with the same amino acid sequence as the protein, and download the PDB files of these proteins;

[0097] (3) Screen a protein with the same function and the same domain as the target protein as a reference protein;

[0098] (4) Using the protein similarity calculation method provided in Method Example 1 to calculate the similarity between the target protein and each reference protein

[0099] (5) The protein with the highest similarity with the target protein is used as the similar protein of the target protein.

[0100] The