Synthesis process of 2-methyl-5-nitroimidazole

[0021] Example 1

[0022] (1) Synthesis reaction: 31% hydrochloric acid is 31% in the reaction kettle, stirred at 2-methylimidazole by 2-methylimidazole at a temperature of 70 ° C; 120 kg of sodium nitrate at 10 ° C; then control temperature 130 ° C The dropped mass fraction was 98% nitric acid 210L, the dropwise speed was 90 kg / h, the dropwise time was 35; the insulation reaction was maintained for 30 min; when the temperature was 10 ° C, when the temperature was 50 ° C, the medium and kettle was added to the drinking water 1300kg. , Cover the human hole cover, transfer the material in the reactor into the neutralization kettle;

[0023] (2) Medium sum, centrifugation: First check the carbonate hydroxine hydroxine hydroxine hydroxine hydroxine hydroxide by 150kg / h in a flow rate of 150 kg / h, and the control material is 100 ° C. When the temperature exceeds 100 ° C, it stops Liquid base, cooling with circulating water to less than 100 ° C, then continuously adding liquid

[0025] Example 2

[0026] (1) Synthesis reaction: 37% hydrochloric acid 27% in the reactor is 37%, stirred down; 2-methylimidazole 280 kg is put into 2-methylimidazole at a temperature of 68 ° C; control temperature 98 ° C 160kg; then control temperature 100 ° C The dropped mass fraction was 90% nitric acid 210L, and the dropped speed was 110 kg / h, and the dropwise time was 3 h; the insulation reaction was maintained at 100 ° C; when the temperature was 50 ° C, the medium and kettle was added to the drinking water 1450kg. , Cover the human hole cover, transfer the material in the reactor into the neutralization kettle;

[0027] (2) Medium and Centrifugation: First check the carnoid hydroxine hydroxine hydroxine hydroxine hydroxide by mass of 145 kg / h in a flow rate of 145kg / h, and the control material is added to 98 ° C. When the temperature exceeds 98 ° C, the addition is stopped The liquid base is cooled to 98 ° C or less, then continued to add liquid base to the neutra

[0029] Example 3

[0030] (1) Synthesis Reaction: Take a mass fraction of 35% hydrochloric acid in the reaction kettle, turn on stirring; 2-methylimidazole 250kg at a temperature of 70 ° C; control temperature 100 ° C is 0.0 kg of sodium nitrate; then control temperature 120 ° C The dropped mass fraction was 93% nitric acid 210L, the dropwise speed was 104.4 kg / h, and the dropwish is 3 h; the incubation reaction is 28 minutes, and it is maintained at 120 ° C; when the temperature is 50 ° C, when it is 50 ° C, add drinking water in the neutral and kettle. 1400kg, covering the human hole cover, transfer the liquid in the reaction kettle into the neutralization kettle;

[0031](2) Medium sum, centrifugation: First check the carbonate hydroxine hydroxine hydroxine hydroxine hydroxine hydroxide by 150kg / h in a flow rate of 150 kg / h, and the control material is 100 ° C. When the temperature exceeds 100 ° C, it stops The liquid base is cooled to 100 ° C below 100 ° C, then conti