Normalized coronary artery microcirculation resistance index calculation method

A coronary and computational method technology, applied in medical science, sensors, catheters, etc., can solve the problems of huge differences in the distribution of values ​​between blood vessels, difficult to accurately refer to coronary arteries, etc.

Pending Publication Date: 2021-11-26
NORTHWESTERN POLYTECHNICAL UNIV
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Problems solved by technology

[0007] However, the microcirculatory resistance calculated by the above-mentioned methods are all absolute microcirculatory resistance values, and the distribution of the values ​​in different parts and blood vessels of different sizes varies greatly, making it difficult to directly provide an accurate reference for the clinical diagnosis of coronary microcirculation disorders

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Embodiment Construction

[0015] The present invention will be described in further detail below in conjunction with the accompanying drawings, but the embodiments of the present invention are not limited thereto.

[0016] The overall flowchart of the calculation method of the normalized coronary microcirculation resistance index is as follows: figure 1 shown. The following will combine figure 1 The specific embodiment will be described in detail.

[0017] 1. Measure the distal and proximal pressure values ​​of the vessel of interest under the maximum hyperemia state: the maximum hyperemia state is induced by drugs, and the pressure guidewire is used to measure the distal and proximal pressure values ​​of the vessel of interest (P a ,P d );

[0018] 2. Reconstruct the three-dimensional model of the vessel of interest based on the angiographic image: Segment the coronary angiographic image taken from multiple angles to obtain the centerline and diameter of the coronary artery respectively; generate ...

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Abstract

The invention provides a normalized coronary artery microcirculation resistance index calculation method. The method comprises the following steps: measuring far-end and near-end pressure values of an interested blood vessel in a maximum hyperemia state; reconstructing an three-dimensional model of the interested blood vessel based on an angiography image, and extracting a blood vessel far-end cross-sectional area at the same time; simulating and calculating blood flow resistance model parameters of the interested blood vessel; calculating the corresponding blood flow volume by combining the pressure values and the blood flow resistance model parameters; and calculating a normalized coronary artery microcirculation resistance index based on the pressure values, the blood flow volume and the blood vessel far-end cross-sectional area. According to the method, the normalized coronary artery microcirculation resistance index calculation method is provided on the basis of the angiography image and the invasive measurement pressure values, so that the unified microcirculation resistance calculation index can be established among blood vessels with different sizes at different parts of the coronary artery.

Description

technical field [0001] The invention relates to the field of calculating coronary artery physiology, in particular to a method for calculating coronary microcirculation resistance using a hemodynamic simulation calculation method. Background technique [0002] The present invention is based on the patented invention of my authorized patent ("Calculation method of blood flow resistance of stenotic lesion based on coronary CT angiography", ZL201710505979.1). [0003] Coronary microcirculatory resistance (microcirculatory resistance, MR) is an effective index to reflect the function of coronary microcirculation, which is defined as the distal coronary artery pressure (P d ) divided by the coronary blood flow (Q max ). Currently it can be calculated by: [0004] (1) The first type of method inserts a guide wire integrated with a pressure sensor and a blood flow sensor into the distal end of the coronary artery, and simultaneously measures pressure and blood flow under the con...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/026A61B5/0215A61B5/00
CPCA61B5/026A61B5/0215A61B5/02158A61B5/7246
Inventor 谢辛舟廉坤陈焱李成祥张瑞晨赵帅郭晓雄李玮昊谢松云
Owner NORTHWESTERN POLYTECHNICAL UNIV
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