4 results about "Clinical diagnosis" patented technology

The invention relates to a pulmonary tuberculosis variation activity marker, a kit, a method and a model construction method, and the pulmonary tuberculosis variation activity marker is characterized in that the pulmonary tuberculosis variation activity marker is a plasma protein biomarker in a blood sample, and the plasma protein biomarker is a combined marker comprising one or more of C1QB protein and CCL19 (MIP3B) protein; a combined marker of C1QB and CCL19 (MIP3B) is used as a biomarker for detecting the activity of pulmonary tuberculosis for the first time, a rapid diagnosis model for detecting the activity of pulmonary tuberculosis is constructed, a new direction is provided for clinical diagnosis of tuberculosis, and as a technical conception for diagnosing the activity of pulmonary tuberculosis, the biomarker provides a new target spot for the diagnosis of the active tuberculosis; therefore, the invention overcomes the defects of low detection rate, long time consumption and the like of the existing active tuberculosis diagnosis, has the characteristics of good specificity and high sensitivity, and has good clinical application value for auxiliary diagnosis of tuberculosis activity.

The invention discloses plasma miRNA markers related to auxiliary diagnosis of colorectal cancer and an application of the marker. The markers may include one or more of miR-103a-3p, miR-127-3p, miR-151a-5p, miR-17-5p, miR-181a-5p, miR-18a-5p and miR-18b-5p. The plasma miRNA markers, as a novel biomarker, have good stability, are minimally-invasive, are easy to obtain and have high sensitivity andspecificity. Development and application of the biomarkers may provide diagnosis and further therapy on various diseases, including tumors, with a new direction; the invention provides the plasma miRNA markers, which have clinical diagnosis potential, for the colorectal cancer targetedly. Researching proves that these miRNAs, as non-invasive markers for diagnosis of the colorectal cancer, has reliability and repeatability.

The invention relates to a DNA library for detecting and diagnosing corneal dystrophy disease-causing genes as well as application of the DNA library. The library comprises 24 disease-causing genes related to corneal dystrophy; 24 corneal dystrophy disease-causing genes are preferably selected, a probe pool is designed, a target area library aiming at the 24 corneal dystrophy disease-causing genesis established, and the library performs sequencing by a high-throughput sequencing technology, looks for disease-cause mutation and provides genetic and molecular biological basis for clinical diagnosis. The library has the characteristics of accuracy, rapidness, flexibility and low cost; 24 gene detection areas can detect various kinds of common corneal dystrophy such as epithelial and subepithelial corneal dystrophy, Bowman's membrane corneal dystrophy, stromal corneal dystrophy, descemet's membrane and corneal endothelium dystrophy; and important significance and clinical value in diagnosis and differential diagnosis on the corneal dystrophy are achieved.