Preparation method and application of surface drug coating of drug balloon

[0035] Example 1

[0036] The present embodiment provides a method for preparing a surface drug coating of a drug balloon, comprising the following steps:

[0037] Prepare the dip coating solution: Weigh 300 mg of paclitaxel and 10 mg of mannitol and dissolve them in 10 mL of acetone, stir for 1 min, and ultrasonicate for 20 min to obtain a supersaturated dip coating solution. The ultrasonic frequency is 60 Hz and the temperature is 35 °C;

[0038] Configure the spraying solution: Weigh 80 mg of paclitaxel and 15 mg of maltol and dissolve them in 6 mL of ethanol, stir for 1 min, and ultrasonicate for 10 min to obtain an unsaturated spraying solution. The ultrasonic frequency is 60 Hz and the temperature is 35 °C;

[0039] Dip coating: keep stirring the dip coating solution at a rotational speed of 50 rps, then put the balloon into the dip coating solution to keep stirring for 5 minutes, take out the balloon and put it in an oven to dry at 40°C for 3 minutes;

[0040] Spraying: P

[0041] Example 2

[0042] The present embodiment provides a method for preparing a surface drug coating of a drug balloon, comprising the following steps:

[0043] Prepare the dip coating solution: Weigh 300 mg of paclitaxel and 10 mg of mannitol and dissolve them in 10 mL of acetone, stir for 1 min, and ultrasonicate for 20 min to obtain a supersaturated dip coating solution. The ultrasonic frequency is 60 Hz and the temperature is 35 °C;

[0044] Configure the spraying solution: Weigh 80 mg of paclitaxel and 15 mg of maltol and dissolve them in 6 mL of ethanol, stir for 1 min, and ultrasonicate for 10 min to obtain an unsaturated spraying solution. The ultrasonic frequency is 60 Hz and the temperature is 35 °C;

[0045] Dip coating: keep stirring the dip coating solution at a rotational speed of 50 rps, then put the balloon into the dip coating solution to keep stirring for 5 minutes, take out the balloon and put it in an oven to dry at 40°C for 3 minutes;

[0046] Spraying: P

[0047] Example 3

[0048] The present embodiment provides a method for preparing a surface drug coating of a drug balloon, comprising the following steps:

[0049] Prepare the dip coating solution: Weigh 300 mg of paclitaxel and 10 mg of mannitol and dissolve them in 10 mL of acetone, stir for 1 min, and ultrasonicate for 20 min to obtain a supersaturated dip coating solution. The ultrasonic frequency is 60 Hz and the temperature is 35 °C;

[0050] Configure the spraying solution: Weigh 80 mg of paclitaxel and 15 mg of maltol and dissolve them in 6 mL of ethanol, stir for 1 min, and ultrasonicate for 10 min to obtain an unsaturated spraying solution. The ultrasonic frequency is 60 Hz and the temperature is 35 °C;

[0051] Dip coating: keep stirring the dip coating solution at a rotational speed of 50 rps, then put the balloon into the dip coating solution to keep stirring for 5 minutes, take out the balloon and put it in an oven to dry at 40°C for 3 minutes;

[0052] Spraying: Put