Process for preparing notoginseng triol saponin and use thereof
A technology of triol saponin and alcohol saponin, which is applied in the preparation field of extracting notoginseng triol saponin from Panax notoginseng, to achieve the effects of fast absorption, inhibition of thrombus formation, and good color
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[0038] Example 1: The chemical composition of notoginseng triol saponins (PTS)
[0039] ①, Notoginsenoside C 1 , D 1 Separation of
[0040] Thin-layer silica gel (10-40μ produced by Qingdao Ocean Chemical Plant) dry packed column (¤42*400mm). PTS is dissolved in dilute alcohol, mixed with thin layer of silica gel, dried at low temperature, and loaded into the top of the column. The lower phase of chloroform-methanol-water (65:35:10) is the developing solvent, which is received by the automatic sampling receiver, each 20ml . TLC identification, spot samples on a high-efficiency thin-layer silica gel plate (produced by Qingdao Ocean Chemical Factory) and unfold it on a horizontal unfolding tank. The unfolding solvent is the same as that of the column chromatography developing agent system. After unfolding, dry it and spray with sulfuric acid ethanol solution. Bake at ℃ for 5 minutes, or hot-air bake with an electric hair dryer, combine the fractions with the same chromatographic spots,
Example
[0103] Example 2: Prepare notoginseng triol saponin according to the following steps:
[0104] A. Take panax notoginseng and crush it through No. 1 sieve, add 60% ethanol and soak for 14 hours, then evenly, compactly fill it into the percolation bucket;
[0105] B. Use 6 times the amount of 60% ethanol to permeate the effluent with no saponin reaction at a flow rate of 3 ml / min per kilogram of medicinal materials. When percolating, the soaking liquid will flow to the full surface first, and then 60% ethanol will be added dropwise. The upper and lower flow rates are equal to each other, and the column cannot be dried;
[0106] C. When the vacuum degree is 0.04Mpa and the temperature is 50-55℃, the percolate is concentrated under reduced pressure, ethanol is recovered, and the concentrated liquid has no alcohol smell, and the relative density is 1.06-1.12;
[0107] D. Add water to 3 times the volume of the concentrated dialysis solution without alcohol, centrifuge, take the clear liq
Example
[0110] Example 3: Prepare panaxatriol saponin according to the following steps:
[0111] A. Take panax notoginseng and crush it through No. 1 sieve, add 90% ethanol and soak for 28 hours, then evenly, compactly fill it into the percolation bucket;
[0112] B. Use 12 times the amount of 60% ethanol to permeate the effluent with no saponin reaction at a flow rate of 7 ml / min per kilogram of medicinal materials. When percolating, the soaking liquid will first flow to the entire liquid surface, and then 60% ethanol will be added dropwise. The upper and lower flow rates are equal to each other, and the column cannot be dried;
[0113] C. When the vacuum degree is 0.08Mpa and the temperature is 50-55℃, the percolate is concentrated under reduced pressure, and ethanol is recovered. The concentrated liquid has no alcohol smell and the relative density is 1.06-1.12;
[0114]D. Add water to 6 times the volume of the concentrated dialysis solution without alcohol, centrifuge, take the clear l
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