Formulations and methods for wound treatment
a wound treatment and formulation technology, applied in the field of formulations and methods for wound treatment, can solve the problems of inability to demonstrate the effect ofinermis /i>, inability to achieve stable wound healing, and inability to use ethanol
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example 1
Formation of the Lawsonia inermis Extract
[0043]10 grams of dried Lawsonia inermis leaves (www.ETSY.com) were placed in a beaker and 100 ml of distilled water were added. The mixture was stirred for 2 hours at room temperature to obtain an aqueous Lawsonia inermis extract designated as a 10% w / w or w / v extract. In order to produce stable wound healing properties of the extract, the antibiotics polymyxin B, clindamycin, and gentamycin were added after extraction in the amount of 0.003% each (30 micrograms / nil). The Lawsonia inermis extract was analyzed for antibiotic activity and for the presence of the antibiotics about two weeks after formation of the extract.
[0044]A zone of inhibition test (Kirby-Bauer Test) was used to evaluate the antibiotic activity against Pseudomonas aeruginosa and Staphylococcus epidermisis. There were six types of tests on each of the bacteria: extract alone, extract plus polymyxin B, extract plus clindamycin, extract plus gentamycin, all three antibiotic
example 2
Treatment of Toe Amputation
[0047]Lawsonia inermis extract, about 8.0% to about 13.0% w / w or w / v, was applied to a wound dressing and then the dressing was applied to the amputated toe of a 68 year-old diabetic patient. The formulation was applied to the wound once a day. FIG. 1A shows the wound at the beginning of treatment. FIG. 1B shows the wound at day 4 of treatment. FIG. 1C shows the wound at day 11 of treatment. The wound was fully healed by day 28 of treatment.
example 3
Treatment of Hysterectomy Incision
[0048]Lawsonia inermis extract, about 8.0% to about 13.0% w / w or w / v, was applied to a wound dressing and then the dressing was applied to the abdomen of a female patient following hysterectomy. The formulation was applied to the wound once a day, so that that the entire surface of the wound was covered with a thin layer of the formulation. FIG. 2A shows the wound at the beginning of treatment. FIG. 2B shows the wound at day 6 of treatment. FIG. 2C shows the wound at day 9 of treatment. FIG. 2D shows the wound at day 16 of treatment. FIG. 2E shows the wound at day 20 of treatment. FIG. 2F shows the wound at day 25 of treatment. Table 1 below represents that approximate dimensions of the wound during the treatment cycle, demonstrating the rapid healing of the wound. The wound healed in just over one month.
[0049]
TABLE 1Approximate WoundDimensionsTreatment (length × width × depth) inDaycentimeters (cm)023 × 3.5 × 9.7622 × 1.5 × 2.8919 × 2.0 × 2.01617
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