Osteogenic Device for Inducing Bone Formation in Clinical Contexts

a technology of osteogenic devices and bone formation, applied in the field of osteogenic devices, can solve the problems of complex surgical procedures, difficult bone repair and regeneration of mandibles, and formidable challenges for skeletal reconstructionists and modern medicin

Inactive Publication Date: 2010-03-18
UNIVERSITY OF THE WITWATERSRAND +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present inventors have developed an implant that can create new tissues called autogenous cartilage within specific areas around teeth after they are extracted from their body during dental procedures like root canal cleaning. This technology could potentially help improve patient's quality of life by promoting better healing processes through regenerative growth factors released inside them themselves.

Problems solved by technology

This patented technical problem addressed in this patent relates to improving the success rate and quality of dental prosthetic restoration used during reconstructive surgery operations without causing complications such as delayed healing or recurrence of cancerous areas within body organs like liver, lung, brain, spine, etc., especially if there were no effective treatment available. Current methods involve delivering drugs directly onto these regions while maintaining good blood supply over time. However, they lack specificities needed for successful therapy across multiple species.

Method used

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  • Osteogenic Device for Inducing Bone Formation in Clinical Contexts
  • Osteogenic Device for Inducing Bone Formation in Clinical Contexts
  • Osteogenic Device for Inducing Bone Formation in Clinical Contexts

Examples

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Embodiment Construction

[0043]The present invention and its preferred embodiments are now described with reference to the accompanying non limiting examples and figures in which:

[0044]FIG. 1 is a clinical photomacrograph illustrating the induction of a large corticalized ossicle upon the implantation of 125 μg hTGF-β3 and delivered by insoluble collagenous bone matrix as a physiologically acceptable delivery vehicle and harvested from the rectus abdominis 30 days after implantation in an adult primate;

[0045]FIG. 2 is a photomicrograph of a histological section of the ossicle shown in FIG. 1 with large quantities of newly formed and mineralized bone in blue with large osteoid seams in orange / red upon the implantation of 125 μg hTGF-β3 and delivered by insoluble collagenous bone matrix as carrier.

[0046]FIG. 3 is a photomicrograph of a histological section of large quantities of newly formed bone upon the implantation of 125 μg hTGF-β3 and delivered by highly crystalline sintered porous hydroxyapatite as a phy

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Abstract

This invention relates to an osteogenic device for the de novo induction of bone formation in a mammal. The device contains a at least one transforming growth factor—&bgr;3 isoform and a retention matrix. The device is introduced by direct injection or surgical implantation into an area where de novo bone formation is desired and, once implanted, the retention matrix acts to retain the TGF-&bgr;3 isoform at its place of introduction and forms a scaffold for generated bone, the induction of which is promoted by the TGF-&bgr;3 isoform. The device may be used to induce bone growth where bone has been debrided in a surgical procedure and it may also be used to transform neoplastic primary and/or metastatic secondary masses into bone thus facilitating surgical debridement thereof.

Description

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Claims

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Application Information

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Owner UNIVERSITY OF THE WITWATERSRAND
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