Injectable microdispersions for medical applications

Synthesis of Poly(glyceryl monolinoleate-succinate)

[0060]29.97 gm (84.6 mmoles) of glyceryl monolinoleate were added to a dry 100 ml, single neck, round bottom flask. A football stir bar was added and a nitrogen inlet adapter was attached. The reaction flask was placed into a room temperature oil bath and a nitrogen blanket was applied. The oil bath temperature was raised to 140° C. Once at 140° C., 8.47 gm (84.6 mmoles) succinic anhydride were added and the temperature was raised to 200° C. Heat tape was wrapped around the outside of the top of the flask and adapter to keep the succinic anhydride from subliming. The reaction was continued for 3 hours at 200° C. The flask was removed from the oil bath and allowed to cool to room temperature. The polymer was a pale yellow, viscous liquid.

[0061]For purification, the polymer was dissolved in Ethyl acetate (5.0 gm polymer in 20 ml EtOAc) and added to a separatory funnel. The solution was washed three times with 20 ml of a very dilute so...

Synthesis of Poly(glyceryl monolinoleate-succinate) High Molecular Weight

[0063]The same procedure as Example 1 was used, except the reaction was maintained at 200° C. for 24 hours.

[0064]GPC measurements determined a number average molecular weight of 6,624, and a weight average molecular weight of 83,214 daltons.

Synthesis of Poly(glyceryl monooleate-succinate)

[0065]30.0 gm (84.1 mmoles) glyceryl monooleate were added to a dry 100 ml, single neck, round bottom flask. A football stir bar was added and a nitrogen inlet adapter was attached. The reaction flask was placed into a room temperature oil bath and a nitrogen blanket was applied. The oil bath temperature was raised to 140° C. Once at 140° C., 8.42 gm (84.1 mmoles) succinic anhydride was added and the temperature was raised to 200° C. Heat tape was wrapped around the outside of the top of the flask and adapter to keep the succinic anhydride from subliming. The reaction was continued for 3 hours at 200° C. The flask was removed from the oil bath and allowed to cool to room temperature. The polymer was a pale yellow, viscous liquid.

[0066]For purification, the polymer was dissolved in Ethyl acetate (5.0 gm polymer in 20 ml EtOAc) and added to a separatory funnel. The solution was washed three times with 20 ml of a very dilute sodium bicarb...