Treatment of cancers characterized by chromosomal rearrangement of the NUT gene

a cancer and gene technology, applied in the field of cancer treatment methods, can solve the problems of nmcs that are very aggressive clinically, respond poorly to conventional chemotherapy, and are almost uniformly fatal, and achieve the effect of slowing down the growth rate of nmcs

Active Publication Date: 2014-01-07
DANA FARBER CANCER INST INC +1
View PDF69 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patented technology described in this patent allows for the identification of specific genetic abnormalities associated with certain cancers such as breast cancer or lymphomas. These abnormalities are caused by changes in DNA structure called mutations. By detecting these abnormalities, researchers may better identify possible causes of disease and develop new therapies targeted towards them.

Problems solved by technology

The technical problem addressed in this patent text relates to the development of drugs targeted at specific parts of the brain called NMCs. While previous researchers have identified various types of NMCs, they were unable to identify them unless there were any significant differences in gene expression. However, current methods such as immunohiston dye transferring, histone deacetylation enzyme inhibitors, and histone deacetyltransferase inhibitors have shown promise in identifying new targets for therapies aiming towards treatments for NMCs.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

examples

[0032]The results obtained from experiments, and conclusions drawn based on the results, may be summarized as follows:

[0033]A. Association of BRD-NUT with Decreased Acetylation and Transcription

[0034]Expression profiling was performed using two NMC cell lines, TC-797 (Toretsky, et al., Am. J. Clin. Oncol. 26(3):300-306 (2003)) and PER-403 (Kees, et al., Am. J. Ped. Hematol. / Oncol. 13(4):459-464 (1991)) treated with control or NUT siRNA. Twenty-four hours following knockdown of BRD4-NUT in the two NMC cell lines, prior to the phenotypic features of differentiation, the number of upregulated genes was found to vastly outnumber the number of genes that are downregulated, as quantified on whole-genome expression array chips (Affymetrix HGU-133 plus 2.0).

[0035]Immunoblots of the NMC cell lines TC-797 and PER-403 (Kuzume, et al., Intn'l J. Cancer 50(2):259-264 (1992)) treated with NUT siRNA or control siRNA revealed a global increase in acetylated histone H4, H3K18, and H4K8 in response to

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Massaaaaaaaaaa
Massaaaaaaaaaa
Electrical conductanceaaaaaaaaaa
Login to view more

Abstract

The present invention is directed, inter alia, to methods of treating NUT midline carcinoma (NMC) by administering compounds that promote increased histone acetylation. The invention also includes assay methods for determining the responsiveness of NMC to specific histone deacetylases and other compounds.

Description

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Owner DANA FARBER CANCER INST INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap