The invention discloses a Zn-Sr series zinc alloy as well as a preparation method and application of the Zn-Sr series zinc alloy. The zinc alloy comprises Zn and Sr, wherein the mass percent of Sr in the zinc alloy ranges from 0% to 10%, but is not equal to 0. The zinc alloy also comprises trace elements including Si, P, Li, Ag, Sn and at least one selected from rare earth elements, wherein the mass percent of the trace elements ranges from 0% to 3%, but is not equal to 0. The mechanical property of the Zn-Sr series zinc alloy disclosed by the invention meets the requirements for strength and toughness of a medical implant material, is nontoxic and favorable in tissue compatibility and blood compatibility, can be degraded by using body fluid and can be applied to preparation of medical implants; and the dissolved metal ions can be absorbed and utilized by living bodies to promote bone growth or can be discharged out of bodies through metabolism.