The invention provides a secondary cooling method and device for a continuous casting machine. The method comprises the following steps of: arranging a plurality of secondary cooling subareas in a casting direction, wherein each secondary cooling subarea comprises at least one cooling unit; arranging a plurality of spraying collector tube outlets in a spraying collector tube, wherein each sprayingcollector tube outlet is connected with a corresponding spray nozzle pipeline and a corresponding spray nozzle; introducing a cooling medium into the spraying collector tube through spraying collector tube inlets, and spraying and impacting the cooling medium to the surface of cast blank to perform secondary cooling through the multiple spray nozzles; and independently controlling each secondarycooling subarea by regulating pressure and flow of the cooling medium. According to the secondary cooling method provided by the invention, outflow amount of single spray nozzle can be controlled andregulated, so that secondary spraying water amount inside single subarea is close to linear changes, smooth transition of secondary cooling water amount between every two adjacent subareas is guaranteed, cooling uniformity of the secondary cooling subareas is improved, stress concentration of cast blank and crack generating probability are reduced, cost increase is hardly generated, and operability is strong, and therefore, the secondary cooling method has a very wide market and a very wide application prospect.