2 results about "Diagnostic Specificity" patented technology

The invention relates to a novel application of small molecule metabolites 2-piperidone and sphingomyelin (SM) 30: 1 in a serum sample as a combined marker in preparation of a kit for diagnosing children asthma. The invention further relates to a kit for detecting asthma in a subject, and whether the subject suffers from asthma or not is judged by detecting the respective concentrations of the combined markers in serum of the subject, calculating the variable Prob of the combined markers based on a binary logistic regression equation and judging an intercept point value. The kit has the characteristics of low detection cost and good stability. The kit can be used for assisting clinical diagnosis of asthma, has the characteristics of high diagnosis specificity and high sensitivity, and has relatively high development and application values.

The present inventions provides combinations of primers and probes for performing quantitative PCRs that can be used to determine the methylation state and level of BMP3 gene and NDRG4 genes in a patient in need thereof, which leads to surprisingly high diagnostic specificity and sensitivity for diagnosing the presence or the absence of colorectal cancer (CRC) and / or advanced adenoma (AA) in a patient in need therefore. Compositions and methods for performing the diagnosis are provided.