The invention discloses application of FXYD3
protein or a coding
gene thereof as a target spot in preparation of a
medicine for preventing and treating
psoriasis, and relates to the technical field of biological
medicine. The invention finds that FXYD3
protein promotes the development of
psoriasis, compared with a
wild type (FXYD3flox / flox) mouse, an IMQ induced mouse
psoriasis model has the advantages that the
skin thickness, the scale and the epidermal thickness of an
epidermal keratinocyte deleted FXYD3 (K14cre FXYD3flox / flox) mouse can be obviously reduced, the IL-17
signal and the expression of downstream chemotactic factors CXCL1 and CCL20 and antibacterial peptides S100A8 and S100A9 can be obviously reduced by deleting FXYD3 in keratinocytes, and the application of FXYD3
protein in inducing psoriasis in the mouse model has the advantages that the development of psoriasis is promoted; the
immune cell infiltration is reduced, so that the psoriasis process is weakened. Therefore, the discovery of the invention indicates that the FXYD3 protein or the coding
gene thereof can be used as a new action target for preventing and treating psoriasis.