Asia 1 type foot and mouth disease virus antigen and preparation and application thereof
A technology of foot-and-mouth disease virus and antigen, which is applied in the fields of application, antiviral agent, botany equipment and method, etc., can solve the problems of limitation and toxicity application, and achieve good immunogenicity effect
Active Publication Date: 2015-06-24
LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
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In addition, studies have shown that E. coli heat-sensitive enterotoxin ( LT ) has proven to
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[0023] The preferred embodiments of the present invention will be described below in conjunction with the accompanying drawings. It should be understood that the preferred embodiments described here are only used to illustrate and explain the present invention, and are not intended to limit the present invention.
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Abstract
The invention discloses a nucleotide sequence opti-LTB-Asia 1/VP1 and a recombinant vector pC 1300/opti-LTB-Asia 1/VP1 containing the sequence. The invention further discloses fusion expression mucosal immune adjuvant Asia 1 type foot and mouth disease virus antigen prepared by using the recombinant vector pC 1300/opti-LTB-Asia 1/VP1 and an application thereof. The antigen expressed by transgenic tomatoes has good immunogenicity. The transgenic tomatoes only express sigmasubunit antigen, do not contain pathogenic microorganisms or potential pathogenic microorganisms and are safe for human and livestock and free of pathogen pollution. An extraction and purification process is not required by producing immunogen through transgenic plants, and the antigen, the preparation and the application have the advantages of being simple in process, good in immune effect and protective effect on animals and the like and are suitable for immunity of livestock.
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Owner LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
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