Compound cold oral solution and preparation method thereof

[0044] A compound cold oral solution, the formula of which is:

[0045]

[0046]

[0047] The preparation method is:

[0048] S1. Heat purified water with a capacity equivalent to 40% of the total amount of sucrose to boiling, and add sucrose and stir to dissolve;

[0049] S2. Add methylephedrine hydrochloride and chlorpheniramine maleate into the caramel, stir well, and set aside;

[0050]S3. Add the caramel solution containing methylephedrine hydrochloride and chlorpheniramine maleate to the sucrose solution in step S1, stir well, then add purified water to 7L, add acetaminophen, Potassium guaiacol sulfonate, caffeine, dextromethorphan hydrobromide, vitamin B2, add propylparaben (stir with purified water or a small amount of alcohol to dissolve before pouring in), mix and dissolve to obtain raw materials liquid;

[0051] S4. Add the raw material liquid into purified water to make the total volume 10L, stir well, keep the pH value at 5.2-5.8, heat to boiling, and keep t

[0055] A compound cold oral solution, the formula of which is:

[0056]

[0057]

[0058] The preparation method is:

[0059] S1. Heat purified water with a capacity equivalent to 40% of the total amount of sucrose to boiling, and add sucrose and stir to dissolve;

[0060] S2. Add methylephedrine hydrochloride and chlorpheniramine maleate into the caramel, stir well, and set aside;

[0061] S3. Add the caramel solution containing methylephedrine hydrochloride and chlorpheniramine maleate to the sucrose solution in step S1, stir well, then add purified water to 7L, add acetaminophen, Potassium guaiacol sulfonate and caffeine are added to propylparaben (stir with purified water or a small amount of alcohol before adding to dissolve and then pour in), mix and dissolve to obtain a raw material solution;

[0062] S4. Add the raw material liquid into purified water to make the total volume 10L, stir well, maintain the pH value at 5.2-5.8, heat to boiling, and maintain the tempe