Depressive disorder biomarker and use thereof

A biomarker and depression technology, applied in the field of biomedicine, can solve problems such as depression that needs to be improved, and achieve the effects of facilitating early prediction, improving diagnostic accuracy, and simplifying the diagnostic process

Inactive Publication Date: 2017-04-05
SHENZHEN KANGNING HOSPITAL SHENZHEN MENTAL HEALTH INST SHENZHEN MENTAL HEALTH CENT
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology helps identify specific strains called Clostridiurn bacilliforme (Cb) and Hydrochlorothrix johnsonii (HCT), both types being found associated with depressure symptoms such as anxiety disorders caused by stressors like alcohol consumption. By testing these microorganisms alongside other organism's gene expressions patterns, this method allows us to predict how likely an individual may have been affected over time without relying solely upon their own personal experiences.

Problems solved by technology

This patented technical problem addressed in this patents relates to improving understanding how depressed individuals develop into more serious conditions such as losing their confidence or being unable to communicate effectively due to reduced motivations caused by negative feelings associated with them.

Method used

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  • Depressive disorder biomarker and use thereof
  • Depressive disorder biomarker and use thereof
  • Depressive disorder biomarker and use thereof

Examples

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Embodiment 1

[0064] In this example, high-throughput sequencing was used to analyze stool samples from healthy people and patients with depression in batches. Based on the high-throughput sequencing data, a statistical test is performed on the healthy population and the depression patient population, so as to determine the specific nucleic acid sequence related to the depression patient population. Specific steps are as follows:

[0065] 1. Sample source

[0066] Depression group: 18 outpatients and inpatients in Shenzhen Kangning Hospital from January 2015 to 2016 were selected, including 10 males and 8 females. The age of the patients was 44.73±12.54 years old, and the BMI index was (22.59± 3.76), the total course of disease was (94.18±64.97) months, and the number of attacks was (4.68±9.21) times. Inclusion criteria: ①Meet the diagnostic criteria of ICD-10 and DSM-5 for unipolar depression; ②Age between 30-65 years old, with 2 or more episodes; ③(Hamilton Depression Rating Scale (HAMD-17

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Abstract

The invention provides a depressive disorder biomarker. The depressive disorder biomarker comprises Clostridium saccharolyticum and Heliobacterium modesticaldum, and also comprises Capnocytophaga, Saccharomonospora viridis, Helicobacter felis, Ruminococcus, Acidaminococcus Rogosa, Acidaminococcus and Acidaminococcus fermentans. The invention further provides a kit for diagnosis of depressive disorder, a composition for preventing or treating depressive disorder and a system for screening a biological sample susceptible to depressive disorder. The system can screen a biological sample susceptible to depressive disorder. The invention further provides a screening method of the biomarker for diagnosis of depressive disorder. The method can screen the biomarker for diagnosis of depressive disorder.

Description

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Claims

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Application Information

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Owner SHENZHEN KANGNING HOSPITAL SHENZHEN MENTAL HEALTH INST SHENZHEN MENTAL HEALTH CENT
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