Single-cell mass spectrometry system and method

[0040] Example 1:

[0041] Single cell mass spectrometry system, a single cell mass spectrometry system comprising:

[0042] Mass spectrometer having the inlet, such as inlet cone;

[0043] Microfluidic chips, the microfluidic chip having a liquid inlet and a plurality of liquid passages; said plurality of liquid channels arranged in the interior of the microfluidic chip, and communicates with the liquid inlet; an outlet of said liquid passage having ;

[0044] Capturing a plurality of cell units, the cell capturing unit disposed within said liquid passage for capturing a single cell;

[0045] Isolation unit, said isolation unit needs to be used to isolate the two liquid passage according to; the spacer and the isolation means comprises a drive module;

[0046] A plurality of electrodes, said electrodes disposed inside or outside the liquid passage;

[0047] A mobile unit, the mobile unit for driving the microfluidic chip, or a mass spectrometer inlet, such that the outlet is selecti

[0061] Example 2:

[0062] APPLICATION EXAMPLE mass spectrometry system and method of the single cell of Example 1 according to an embodiment of the present invention.

[0063] In this application example, as Figure 1-3 , The microfluidic chip three-layer structure, the third layer structure: a plurality of parallel processing on the body 13 and aligned rectangular recess 31 as a liquid passage, an open end of the rectangular grooves 31 (i.e. an outlet liquid passage) of small width, a plurality of rectangular recesses 31 in the other open end 32 having a communication (i.e. communication arcuate recess sidewall portion), connected to the side wall and the bottom wall portion having a ramp; body 13 having a liquid inlet through hole 35, the communicating portion 35 communicates through the groove 34 through hole; the main body 13 in the processing, each of the rectangular grooves integrally formed with a single 41 cell capturing unit 31, i.e. three rectangular grooves perpendicular t

[0075] Example 3:

[0076] The application of mass spectrometry embodiment of a single cell system and method of the embodiment of the present invention, Example 1, Example 2, except that:

[0077] 1. no longer a fluid passage, i.e. no longer set of flexible material and the first layer, the third layer a layer of material closing the recess to the original;

[0078] 2. The microvalve disposed within the fluid passage, and to achieve isolation between the communicating passage and the liquid communicating portion; microvalve is prior art in the field of microfluidics, a specific configuration and mode of operation are not repeated here.