Composite adjuvant and novel coronavirus COVID-19 recombinant protein vaccine using composite adjuvant

A COVID-19, recombinant protein technology, applied in the field of new crown COVID-19 recombinant protein vaccine, can solve the problems of limited immune enhancement, pain, allergies, etc., and achieve the effect of rapid preparation

Pending Publication Date: 2021-10-22
SINOVAC RES & DEV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above-mentioned adjuvants are widely approved for use in vaccine preparation, in practical applications, low doses of aluminum salt adjuvants alone have limited immune

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composite adjuvant and novel coronavirus COVID-19 recombinant protein vaccine using composite adjuvant
  • Composite adjuvant and novel coronavirus COVID-19 recombinant protein vaccine using composite adjuvant
  • Composite adjuvant and novel coronavirus COVID-19 recombinant protein vaccine using composite adjuvant

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0041] Example 1

[0042] This embodiment provides a composite adjuvant composed of CpG oligodeoxynucleotide and aluminum hydroxide; wherein, the mass ratio of CpG oligodeoxynucleotide and aluminum hydroxide is 1:0.6.

[0043] This embodiment further provides a combination of the compound adjuvant and the novel coronavirus COVID-19 recombinant vaccine.

[0044] Specifically: add CpG oligodeoxynucleotide adjuvant and aluminum hydroxide adjuvant to the vaccine stock solution filtered by a 0.22 μm filter membrane, so that the concentration of CpG adjuvant is 0.5 mg / dose and the content of aluminum hydroxide adjuvant is 0.3 mg / dose, vaccine antigen content 20μg / dose. The vaccine number obtained in this example is recorded as 20200401.

Example Embodiment

[0045] Example 2

[0046] This embodiment provides a composite adjuvant composed of CpG oligodeoxynucleotide and aluminum hydroxide; wherein, the mass ratio of CpG oligodeoxynucleotide and aluminum hydroxide is 1:0.6.

[0047] This embodiment further provides a combination of the compound adjuvant and the novel coronavirus COVID-19 recombinant vaccine.

[0048] Specifically: add CpG oligodeoxynucleotide adjuvant and aluminum hydroxide adjuvant to the vaccine stock solution filtered by a 0.22 μm filter membrane, so that the concentration of CpG adjuvant is 0.5 mg / dose and the content of aluminum hydroxide adjuvant is 0.3 mg / dose, vaccine antigen content 40μg / dose. The vaccine number obtained in this example is recorded as 20200402.

Example Embodiment

[0049] Example 3

[0050] This embodiment provides a composite adjuvant composed of CpG oligodeoxynucleotide and aluminum hydroxide; wherein, the mass ratio of CpG oligodeoxynucleotide and aluminum hydroxide is 1:0.9.

[0051] This embodiment further provides a combination of the compound adjuvant and the novel coronavirus COVID-19 recombinant vaccine.

[0052] Specifically: add CpG oligodeoxynucleotide adjuvant and aluminum hydroxide adjuvant to the vaccine stock solution filtered by 0.22 μm filter membrane, so that the concentration of CpG adjuvant is 0.5mg / dose, and the content of aluminum hydroxide adjuvant is 0.45mg / dose, vaccine antigen content 20μg / dose. The vaccine number obtained in this example is recorded as 20200403.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Chain lengthaaaaaaaaaa
Login to view more

Abstract

The invention discloses a composite adjuvant containing CpG oligodeoxynucleotide and an aluminum adjuvant, and a novel coronavirus COVID-19 recombinant protein vaccine using the composite adjuvant. The CpG oligodeoxynucleotide and the aluminum adjuvant are compounded for use, so that a strong immunological enhancement effect can be generated. When the composite adjuvant is applied to the novel coronavirus COVID-19 recombinant protein vaccine, the residence time of the novel coronavirus COVID-19 recombinant protein vaccine in vivo can be prolonged to a great extent, and the hydrolysis effect of various hydrolases on the novel coronavirus COVID-19 recombinant protein vaccine is reduced. The novel coronavirus COVID-19 recombinant protein vaccine using the composite adjuvant has the advantages of simple preparation method, easy quality control, easy large-scale production, good safety and low toxic and side effects, and is especially suitable for prevention and treatment of novel coronavirus COVID-19 in various people, including middle-aged and elderly people with low immune functions.

Description

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Owner SINOVAC RES & DEV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap