Whole blood simulation liquid for in-vitro test of hollow fiber blood purification device

[0045] The composition of the whole blood simulated liquid (substitute whole blood) is as follows:

[0046] Polystyrene microspheres with a diameter of 6 μm and a simulated liquid with a volume ratio of 28:100, the simulated liquid includes 30wt% bovine serum albumin, 3wt% myoglobin and 1wt% lysozyme, and the balance is water.

[0047] Whole bovine blood was used as the control group.

[0048] The present invention adopts figure 1 The shown monitoring device changes with time the transmembrane pressure of whole blood simulated liquid and bovine whole blood, and the test data are shown in Table 1;

[0049] Table 1 The transmembrane pressure of the whole blood simulated fluid of Example 1 changing over time

[0050] time / min Transmembrane pressure of bovine whole blood (mmHg) The transmembrane pressure (mmHg) of embodiment 1 0 44.6 48.0 10 45.7 48.7 20 46.3 48.8 30 46.5 49.8 40 47.4 50.4 50 47.9 51.0 60 48.3 51.2 70 4

[0053] The composition of the whole blood simulated liquid (substitute whole blood) is as follows:

[0054] Silicon dioxide with a diameter of 6 μm and a simulated liquid with a volume ratio of 30:100, the simulated liquid includes 30 wt% bovine serum albumin, 3 wt% myoglobin and 1 wt% lysozyme, and the balance is water;

[0055] Whole bovine blood was used as the control group.

[0056] The present invention adopts figure 1The shown monitoring device changes with time the transmembrane pressure of whole blood simulated liquid and bovine whole blood, and the test data are shown in Table 1;

[0057] The transmembrane pressure of the whole blood simulated liquid of table 2 embodiment 2 changing over time

[0058] time / min Transmembrane pressure of bovine whole blood (mmHg) The transmembrane pressure (mmHg) of embodiment 2 0 44.6 48.6 10 45.7 49.0 20 46.3 49.2 30 46.5 49.1 40 47.4 49.7 50 47.9 50.0 60 48.3 50.5 70 48.6

[0061] The composition of the whole blood simulated liquid (substitute whole blood) is as follows:

[0062] Polystyrene microspheres with a diameter of 6 μm and a simulated liquid with a volume ratio of 28:100, the simulated liquid includes 10wt% dextran with a molecular weight of 70kDa, 15wt% albumin and 1wt% lysozyme, and the balance is water;

[0063] Whole bovine blood was used as the control group.

[0064] The present invention adopts figure 1 The shown monitoring device changes with time the transmembrane pressure of whole blood simulated liquid and bovine whole blood, and the test data are shown in Table 3;

[0065] The transmembrane pressure of the whole blood simulated liquid of table 3 embodiment 3 changes over time

[0066] time / min Transmembrane pressure of bovine whole blood (mmHg) The transmembrane pressure (mmHg) of embodiment 3 0 44.6 44.0 10 45.7 44.5 20 46.3 45.0 30 46.5 45.7 40 47.4 46.0 50 47.9 46.2 60