Dementholized mint oil capsule and its prepn process

A technology of peppermint oil and capsule, applied in the field of medicine, can solve the problems of unstable quality, low bioavailability, decreased oral disintegration and the like, and achieves the effects of scientifically advanced preparation method, improved bioavailability and rapid disintegration

Inactive Publication Date: 2005-12-14
广东强基药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are two main forms of peppermint oil in medical applications. The first is to add peppermint oil to starch and mix to make granules, which are packed into hard capsules for use by patients, which has the advantage of being easy to disintegrate and absorb; but as we all know, Peppermint oil is a kind of easily volatile substance. It will continue to volatilize during the process of adding starch, mixing and making granules. The quality and efficacy of peppermint oil will decline due to its own volatilization during transportation, which is also the main reason why the content of products on the market fails to pass the quality inspection process.
[0004] The second is to make mint oil into soft capsules in a liquid state, which can effectively overcome the volatilization defect of mint oil, but the soft capsules in the prior art are mainly made of gelatin and glycerin, and the capsule wall The layer is relatively thick, some reaching more than 0.5mm, and it is easy to solidify after a long time, so that its oral disintegration degree decreases, and even the disintegration is unqualified, which seriously affects the efficacy of the product
To sum up, the peppermint oil capsules in the prior art market are either easy to disintegrate and absorb but unstable in quality, or relatively stable in quality but unstable in disintegration; for these unsatisfactory defects, the applicant has gone through many years Research and practice, and finally developed a newer peppermint oil capsules and its preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0014] Embodiment 1: filling and filling the liquid substance based on peppermint oil in the stomach-dissolved hollow capsule and covering it, and then coating a medicinal sealing material on the covering place to form a sealing tape to seal it, so that the liquid Peppermint oil does not leak that is.

Example Embodiment

[0015] Embodiment 2: filling and filling the liquid substance mainly based on peppermint oil in enteric-coated hollow capsules and fitting them together, and then coating a medicinal sealing material on the fitting place to form a sealing tape to seal it, so that the liquid state Peppermint oil does not leak that is.

Example Embodiment

[0016] Embodiment 3: the stability test of peppermint oil capsule prepared by the present invention and marketed product and self-made soft capsule sample:

[0017] Test sample: (1) 1000 peppermint oil capsules prepared by the method of Example 1

[0018] (2) Danshu Capsules 200 Capsules, a listed peppermint oil capsule product

[0019] (3) Prepare 1000 peppermint oil soft capsules according to the soft capsule preparation method

[0020] Test conditions: The samples were stored for 12 months at a temperature of 30°C and a relative humidity of 60%. After 0, 1, 2, 3, 6, and 12 months, samples were taken to check their disintegration and content;

[0021] Test result: After 12 months of accelerated test, the sample of the present invention disintegrates to meet the requirements, and the content has no obvious change. The disintegration of Danshu Capsules, a marketed product, meets the requirements, but the content varies greatly, while the self-made soft capsu

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PUM

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Abstract

The present invention relates to dementholized mint oil capsule and its preparation process. The capsule consists of hard covering and sealed and contained liquid with dementholized mint oil as main component. The preparation process includes packing liquid medicine inside hard capsule covering, jacketing and sealing, and other technological steps. The prepared capsule, after being taken orally, will disintegrate inside body fast to result in high bioavailability in treating chronic cholecystitis and lithous cholecystitis.

Description

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Claims

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Application Information

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Owner 广东强基药业有限公司
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