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3 results about "Diisopropylamine" patented technology

Diisopropylamine is a secondary amine with the chemical formula (CH₃)₂HC-NH-CH(CH₃)₂. It is best known as its lithium derivative of its conjugate base, lithium diisopropylamide, known as "LDA". LDA is a strong, non-nucleophilic base.

Method for producing isopropylamine

ActiveCN101684073AReduce heatReduce energy costsAmino compound purification/separationPreparation by reductive alkylationReaction temperatureEconomic benefits
The invention discloses a method for producing isopropylamine, which belongs to the technical field of amine. To solve the problem that the prior isopropylamine industrial production device cannot effectively convert diisopropylamine into the isopropylamine, a reactor for an acetone hydroamination reaction performs the sectional control of the reaction temperature, the reaction temperature of a first section positioned at an inlet of the reactor is between 110 and 150 DEG C, and the reaction temperature of a downstream section is 5 to 30 DEG C higher than that of an upstream section which is adjacent to the downstream section. Along with the gradual reduction of the concentration of acetone along a bed, the reaction temperature is improved section by section, which is favorable for converting the diisopropylamine and isopropanol into the isopropylamine, thereby reducing the circulation of the diisopropylamine and the isopropanol, reducing energy consumption, and preventing the diisopropylamine from being gradually accumulated in a system so as not to need operating a diisopropylamine rectification system with difficult operation. The method is simple, feasible and easy to realize,and has considerable industrial application value and economic benefit.
Owner:CHINA PETROLEUM & CHEM CORP +1

Thymopentin methyl ester conjugate and preparation method thereof

InactiveCN106366177AEnhance immune balance regulationSolve the shortcoming that the half-life is only 30 secondsThymopoietinsPeptide preparation methodsN-ethyldiisopropylamineDistillation
The invention relates to a thymopentin methyl ester conjugate and a preparation method thereof. The preparation method specifically comprises the following steps: dissolving Z-FPSDM-Arg(Pbf)-Lys(BOC)-OH and 1-hydroxybenzotriazole (HOBt) / DCC / MMF in anhydrous trichloromethane, adding N,N-ethyldiisopropylamine and other specific solvents for reacting while stirring, thereby obtaining an active ester A; dripping the active ester into an alkaline solution of tripeptide derivatives, adding N,N-diisopropylamine and other specific solvents, thereby obtaining a coarse product of the thymopentin methyl ester conjugate; and finally, performing deprotection, reduced pressure distillation, washing and drying, thereby obtaining an accurately modified thymopentin methyl ester conjugate. The preparation method disclosed by the invention is fewer in byproducts and high in synthetic efficiency. The thymopentin methyl ester conjugate has the effects of maintaining the biological activity of TP-5, relieving or avoiding enzymolysis of TP-5 and further obviously prolonging the in-vivo metabolic half-life, and is extremely high in clinical application value.
Owner:SHANDONG BOCHUANG BIOTECHNOLOGY CO LTD
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