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3 results about "Fibrinogen" patented technology

Fibrinogen (factor I) is a glycoprotein that circulates in the blood of vertebrates. During tissue and vascular injury it is converted enzymatically by thrombin to fibrin and subsequently to a fibrin-based blood clot. Fibrinogen functions primarily to occlude blood vessels and thereby stop excessive bleeding. However, fibrinogen's product, fibrin, binds and reduces the activity of thrombin. This activity, sometimes referred to as antithrombin I, serves to limit blood clotting. Loss or reduction in this antithrombin 1 activity due to mutations in fibrinogen genes or hypo-fibrinogen conditions can lead to excessive blood clotting and thrombosis. Fibrin also mediates blood platelet and endothelial cell spreading, tissue fibroblast proliferation, capillary tube formation, and angiogenesis and thereby functions to promote tissue revascularization, wound healing, and tissue repair.

Bioink composition for cartilage regeneration, method for manufacturing customized scaffold for cartilage regeneration using same, and customized scaffold for cartilage regeneration manufactured using manufacturing method

InactiveUS20210038762A1Improve bindingCartilage differentiation ability andAdditive manufacturing apparatusPharmaceutical delivery mechanismStromal vascular fractionFibrinogen
The present specification relates to a bioink composition for cartilage regeneration, a method for manufacturing a customized scaffold for cartilage regeneration using same, and a customized scaffold for cartilage regeneration using said manufacturing method, the bioink composition comprising: a first liquid comprising an adipose tissue-derived stromal vascular fraction, hyaline cartilage powder, and fibrinogen; and a second liquid comprising thrombin.
Owner:ROKIT HEALTHCARE INC

Method for preparing hemostatic material based on air jet pulverization technology

The invention discloses a method for preparing a hemostatic material based on an air jet pulverization technology. The method comprises the following steps of (1) preparing a fibrinogen solution, wherein the fibrinogen solution comprises the following components of 2.5-3.5 wt% of fibrinogen, 10-25 wt% of trehalose, 2-10 wt% of glycine, 1.0-1.5 wt% of sodium chloride, 0.1-0.6 wt% of sodium citrate, 2.0-2.5 wt% of arginine hydrochloride and the balance of water for injection; (2) performing freeze drying on the fibrinogen solution, and performing air jet pulverization to obtain fibrinogen powder; (3) preparing a thrombin solution, wherein the thrombin solution is prepared from the following components of 0.1 to 0.5 weight percent of thrombin, 1.5 to 5.0 weight percent of trehalose, 0.3 to 1.0 weight percent of calcium chloride, 0.5 to 2.0 weight percent of glycine, 1.0 to 3.0 weight percent of cane sugar, 0.5 to 2.0 weight percent of dextran 20 and the balance of water for injection; (4) performing freeze drying on the thrombin solution, and performing air jet pulverization to obtain thrombin powder; and (5) mixing the fibrinogen powder with the thrombin powder, filling and drying to obtain the hemostatic material. The preparation process is simple, the period is short, and the prepared material is convenient to clinically use and excellent in hemostatic effect and has a wider application prospect.
Owner:FUDAN UNIV
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