Method for preparing hemostatic material based on air jet pulverization technology

[0034] A method for preparing a hemostatic material based on jet milling technology, comprising the steps of:

[0035] One, the preparation of fibrinogen powder:

[0036] (1) Prepare fibrinogen solution: add fibrinogen, trehalose, glycine, sodium chloride, sodium citrate and arginine hydrochloride to water for injection, and stir evenly to obtain the fibrinogen solution; The mass percent of each component in the fibrinogen solution is: 2.5wt% of fibrinogen, 10wt% of trehalose, 2wt% of glycine, 1.0wt% of sodium chloride, 0.1wt% of sodium citrate, 2.0wt% of arginine hydrochloride %, the balance is water for injection;

[0037] (2) Preparation of fibrinogen powder: the fibrinogen solution is placed in a freeze-drying tray, vacuum freeze-dried, and then pulverized by an ultrafine powder jet mill to obtain a fibrinogen powder; the vacuum freeze-dry The process includes: pre-freezing at -55°C for 8 hours, then drying at -5°C for 55 hours, and then secondary drying at 35°C for 12 hour

[0044] A method for preparing a hemostatic material based on jet milling technology, comprising the steps of:

[0045] One, the preparation of fibrinogen powder:

[0046] (1) Prepare fibrinogen solution: add fibrinogen, trehalose, glycine, sodium chloride, sodium citrate and arginine hydrochloride to water for injection, and stir evenly to obtain the fibrinogen solution; The mass percent of each component in the fibrinogen solution is: 3.0wt% of fibrinogen, 15wt% of trehalose, 6wt% of glycine, 1.25wt% of sodium chloride, 0.35wt% of sodium citrate, 2.25wt% of arginine hydrochloride %, the balance is water for injection;

[0047] (2) Preparation of fibrinogen powder: the fibrinogen solution is placed in a freeze-drying tray, vacuum freeze-dried, and then pulverized by an ultrafine powder jet mill to obtain a fibrinogen powder; the vacuum freeze-dry The process includes: pre-freezing at -35°C for 12 hours, then drying at -10°C for 50 hours, and then secondary drying at 25°C for 15

[0054] A method for preparing a hemostatic material based on jet milling technology, comprising the steps of:

[0055] One, the preparation of fibrinogen powder:

[0056] (1) Prepare fibrinogen solution: add fibrinogen, trehalose, glycine, sodium chloride, sodium citrate and arginine hydrochloride to water for injection, and stir evenly to obtain the fibrinogen solution; The mass percent of each component in the fibrinogen solution is: 3.5wt% of fibrinogen, 20wt% of trehalose, 10wt% of glycine, 1.5wt% of sodium chloride, 0.6wt% of sodium citrate, 2.5wt% of arginine hydrochloride %, the balance is water for injection;

[0057] (2) Preparation of fibrinogen powder: the fibrinogen solution is placed in a freeze-drying tray, vacuum freeze-dried, and then pulverized by an ultrafine powder jet mill to obtain a fibrinogen powder; the vacuum freeze-dry The process includes: pre-freezing at -20°C for 15 hours, then drying at 0°C for 65 hours, and then secondary drying at 30°C for 10 hou