The invention discloses high-permeability high-impedance manganese zinc ferrite and a preparation method thereof, and belongs to the technical field of magnetic materials. The novel ferrite material with high magnetic conductivity and high impedance is obtained by optimizing the raw material composition proportion of the main material and the auxiliary material and adjusting the ball-milling sintering process. A nano Tiamp; by doping MoO3, the microstructure of the ferrite can be improved on the whole, a compact structure is formed in the sintering process, pores are reduced, the reaction area is enlarged, the reaction rate is increased, grain growth is promoted, and the magnetic conductivity and impedance are improved. The obtained ferrite material has a high impedance value within the high-frequency range of 1-100 MHz, the applicable working conditions of the manganese-zinc ferrite are effectively widened, the practicability is high, and the market prospect is wide.