Diminazene aceturate production method

[0038] (1) Preparation of p-nitrobenzonitrile:

[0039] A, make solvent dissolving p-nitrobenzamide with toluene, make p-nitrobenzamide solution; The parts by weight of p-nitrobenzamide are 70, and the parts by weight of toluene are 800;

[0040] B, the p-nitrobenzamide solution is dropped into the reaction kettle, add triethylamine and thionyl chloride to react, set the reaction temperature to be 100°C, and the reaction time is 10h; the parts by weight of triethylamine are 4; chlorine The parts by weight of sulfoxide is 95;

[0041] C, cool down to 20°C, add 500 parts by weight of water and stir for 20 minutes to dilute, add a concentration of 30% sodium hydroxide solution to neutralize to a pH value of 7, filter and put it into a separatory kettle to separate the water. The temperature of the toluene layer was raised to 110°C to distill the toluene out, and the toluene was distilled out in a filter rejection machine, and then dried at 60°C to obtain a p-nitrobenzonitrile filte

[0057] (1) Preparation of p-nitrobenzonitrile:

[0058] A, make solvent dissolving p-nitrobenzamide with toluene, make p-nitrobenzamide solution; The parts by weight of p-nitrobenzamide are 80, and the parts by weight of toluene are 900;

[0059] B, p-nitrobenzamide solution is dropped into the reaction kettle, add triethylamine and thionyl chloride to react, set the reaction temperature to be 110°C, and the reaction time is 12h; the parts by weight of triethylamine are 5; chlorine The parts by weight of sulfoxide is 100;

[0060] C, cool down to 30°C, add 620 parts by weight of water and stir for 30 minutes to dilute, add a concentration of 30% sodium hydroxide solution to neutralize to a pH value of 7, filter and put it into a separatory kettle to separate the water. The temperature of the toluene layer was raised to 110°C to distill the toluene out, and the toluene was distilled out in a filter rejection machine, and then dried at 60°C to obtain a p-nitrobenzonitrile filter c