In-vivo platelet instant label-free detection system and detection method

A detection system and detection method technology, applied in the directions of diagnostic recording/measurement, blood characterization device, medical science, etc., can solve the problem that real-time, full-time and instant detection cannot be realized, and achieve the effect of avoiding waiting time and convenient detection.

Pending Publication Date: 2016-10-26
MAGASSIST INC
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  • Abstract
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  • Claims
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AI Technical Summary

Problems solved by technology

[0006] However, the above-mentioned tests are all in vitro tests or rely on biomar

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0062] Example one:

[0063] Taking the surface of an artificial heart assist device made of a titanium-based alloy as an example, a diamond film deposition process is used on the surface to form a diamond MEMS sensor on the surface of the titanium-based alloy, and the geometrical distribution design on the surface of the artificial heart is optimized.

[0064] Then conduct an in vitro simulation experiment, connect the artificial heart with a dynamic blood flow simulator, and simulate the flow field after the artificial heart intervention. The experiment uses the donor’s blood for testing. The output results are compared in two stages. The first is to compare with the computational fluid dynamics simulation results with a thrombus prediction module. The second is to compare the monitoring results at different time points with the fluorescence microscope method. The microthrombus distribution on the surface was compared. In this way, the sensitivity of the sensor surface and the accu

Example Embodiment

[0066] Embodiment two:

[0067] In this embodiment, the diamond MEMS sensor is prepared on the surface of the blood vessel stent or artificial blood vessel to detect the surface blood flow rate.

[0068] The MEMS electrode forms an electric field on the diamond surface. Under different blood flow rate conditions, the surface electric field will also change, which will be fed back to the diamond MEMS sensor to obtain the electrical signal change. Such as Image 6 The current density kinetic curve of the thrombosis process in the body is shown (the dots are the data points). It can be seen that as time progresses, platelets gradually aggregate to form coagulation, and the current density gradually increases.

[0069] By analyzing the changes of electrical signals and the regional concentration information of red blood cells and plasma through a fixed algorithm, the blood flow rate on the surface of the device can be obtained in real time, thereby obtaining the space, coagulation time and

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Abstract

The invention discloses an in-vivo platelet instant label-free detection system. The detection system comprises a signal acquisition unit, a signal receiving unit and a signal processing unit, wherein the signal acquisition unit comprises a diamond MEMS sensor which is arranged in vivo; the diamond MEMS (micro-electro-mechanical system) sensor comprises a PC diamond thin film and electrodes which are arranged on the PC diamond thin film and are formed by conductive diamonds; the signal acquisition unit is used for acquiring kinetics signals of electrode process of platelet near-wall time-space distribution; the signal receiving unit is connected to the signal acquisition unit and is arranged in vitro, and the signal receiving unit is used for receiving the signals acquired by the signal acquisition unit; and the signal processing unit is connected to the signal receiving unit and is arranged in vitro, and the signal processing unit is used for quantitative characterization of platelet time-space distribution in accordance with the signals received by the signal receiving unit. The detection system and the detection method disclosed by the invention, which adopt in-vivo detection, can avoid an operation of extracting blood for in-vitro detection, so that the detection is facilitated; through label-free detection, the detection system and the detection method are safe and nondestructive to the blood; and through instant detection, the problem of an existing detection method which is asynchronous in waiting time as well as detection and result acquisition.

Description

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Claims

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Application Information

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Owner MAGASSIST INC
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