Chinese and western medicine composition for improving hypoglycemic ineffectiveness of oral metformin and preparation method and application thereof

[0053] Embodiment 1: A Chinese and Western medicine composition provided by the present invention, the composition is composed of the following components by weight: 1.5 parts of metformin preparation containing 0.5 g of pharmaceutical ingredients, 5 parts of Scutellaria baicalensis, 5 parts of Radix Paeoniae Alba, 5 parts of Radix Glycyrrhizae portion, 5 portions of jujube.

[0054] Its preparation method is as follows: (1) Scutellaria baicalensis, white peony root, roasted licorice, and jujube are crushed and passed through a 10-mesh sieve, soaked in 5 times the amount of water for 0.6h, then heated in sequence (heating temperature is 100°C), fried Boil and extract 2 times, each time for 1.2h, filter, combine the filtrate, concentrate under reduced pressure, the density measured at 60°C is 1.05g / ml, to obtain a thick paste;

[0055] (2) Add ethanol with a mass concentration of 95% to the thick paste obtained in step (1), until the mass concentration of alcohol in the thick pa

[0059] Embodiment 2: A kind of Chinese and western medicine composition provided by the present invention, this composition is made up of the following components by weight: 2 parts of metformin preparations containing 0.5g of medicinal ingredients, 15 parts of Scutellaria baicalensis, 10 parts of Radix Paeoniae Alba, 9 parts of Radix Glycyrrhizae portion, 9 portions of jujube.

[0060] Its preparation method is as follows: (1) Scutellaria baicalensis, white peony root, roasted licorice, and jujube are crushed and passed through a 10-mesh sieve, soaked in 8 times the amount of water for 0.5h, and then heated in sequence (heating temperature is 100°C), Decocting and extracting 2 times, 1 hour each time, filtering, combining the filtrates, concentrating under reduced pressure, the density measured at 60°C was 1.10g / ml, to obtain a thick paste;

[0061] (2) Add ethanol with a mass concentration of 95% to the thick paste obtained in step (1), until the mass concentration of alcohol

[0065] Embodiment 3: A kind of Chinese and Western medicine composition provided by the present invention, comprises the following parts by weight composition and 0.5 part of the metformin preparation containing 0.5g medicinal composition; jujube 15 parts).

[0066] (1) Scutellaria baicalensis, Radix Paeoniae Alba, Radix Glycyrrhizae, and Jujube are crushed by the weight of the medicinal materials, passed through a No. 1 sieve (10 mesh), soaked in 10 times the amount of water for 0.4 hours, heated (heating temperature is 100°C), decocted and extracted 2 times, each time 1.2h, filter, combine the filtrate, concentrate under reduced pressure, the density measured at 60°C is 1.13g / ml, to get a thick paste;

[0067] (2) Add 95% ethanol to the above thick paste until the alcohol concentration is 80%, mix well, let it stand for 12 hours, take the supernatant, concentrate under reduced pressure, the density measured at 60°C is 1.15g / ml, add microcrystalline Pharmaceutical excipient