CHA gelatin stent

A gelatin and the obtained technology are applied in the fields of medical science, prosthesis, tissue regeneration, etc., which can solve the problems of poor seed cell regeneration and differentiation, and unsatisfactory treatment effect, so as to promote osteogenesis, improve mechanical properties, and avoid secondary effect of surgery

Inactive Publication Date: 2021-10-22
SECOND AFFILIATED HOSPITAL OF COLLEGE OF MEDICINEOF XIAN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present technology relating to improving the mechanic performance of biomaterials by adding an organopolysiloxane (OPS) polymer that holds calcium phosphate crystals together within its structure. Collagens are natural materials found throughout animal tissues such as skin or muscle fibres from animals like cows or sheep. These proteins help create strong structures inside these types of material without having any permanent damage they may cause after implantation due to their high tensile modulus compared to other synthetic substances commonly used for this purpose. Additionally, it suggests using different translational movements between two protein molecules called chains when making bones through injecting solutions containing them onto specific locations on those surfaces. Overall, this new method allows scientists to use existing techniques to improve the quality control and effectiveness of medical devices made up of biocompatible materials.

Problems solved by technology

This patented technical problem addressed by this patents relates to improving the ability of autogenous or allogeneic human tissue derived from adult skeletons to form new cartilage structures during healing processes due to their unique properties such as being able to develop chondrocytes without damaging them when implanted back together under loadings on specific areas of the body's surface called calcaneus.

Method used

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  • CHA gelatin stent
  • CHA gelatin stent
  • CHA gelatin stent

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Embodiment Construction

[0020] The present invention will be described in detail below in conjunction with specific embodiments. The following examples will help those skilled in the art to further understand the present invention, but do not limit the present invention in any form. It should be noted that those skilled in the art can make several modifications and improvements without departing from the concept of the present invention. These all belong to the protection scope of the present invention.

[0021] Membrane detection

[0022] One: XRD machine, FTIR spectrometer

[0023] Using RINT 2500V XRD machine and Fourier Transform Infrared (FTIR) spectrometer to detect the samples, figure 1 FTIR spectra of Gel-CHA00 and Gel-CHA05 scaffolds are shown. For Gel-CHA05, the absorption peak at a wavelength of 3424 cm- is related to the stretching vibration of the -OH group; the amide II band at 1638-1655 cm- is caused by the stretching vibration of the C=O bond. There is a characteristic absorption pe

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Abstract

The invention discloses a CHA gelatin stent which is prepared by the following steps: dissolving 5g of B-type gelatin from bovine bone into 50ml of distilled water containing sodium citrate dehydrate to serve as a dispersing agent; after the gelatin is completely swelled, adding 0.37 g of calcium hydroxide, and mixing for 30 minutes by using a magnetic stirrer at 37 DEG C at the rotating speed of 200 rpm; diluting 0.24 g of phosphoric acid in 50 ml of distilled water, and titrating the obtained phosphoric acid solution into the gelatin hydrogel solution for 15 minutes; continuing the synthesis maturity for 3 hours, regularly controlling the pH, and finally regulating the pH to 7.4; weighing 9.5 g of a Gel-CHA05 solution and pouring into a solution culture dish of 8 x 8 cm < 2 >, drying the solution culture dish in a refrigerator of 4 DEG C and then placing in a vacuum oven to be heated at 142 DEG C for 72 h so as to induce cross-linking formation of the stent, and performing gas sterilization in low-temperature ethylene oxide.

Description

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Claims

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Application Information

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Owner SECOND AFFILIATED HOSPITAL OF COLLEGE OF MEDICINEOF XIAN JIAOTONG UNIV
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