Preparation process and application of inorganic salt nanometer particle containing biological active material and enveloped Chinese medicinal ingredient
A technology of biologically active substances and nanoparticles, applied in the field of drug and vaccine delivery systems, to achieve the effects of increased dispersion rate, high stability, and easy industrialization
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Embodiment 1
[0042] Embodiment 1: the preparation method and application of inorganic salt nanoparticles encapsulated with human growth hormone (hGH) containing traditional Chinese medicine flavonoids and saponins
[0043] preparation before preparation
[0044] Salt solution: prepare 0.01-1.0 mole manganese chloride (or magnesium chloride, or calcium chloride solution) with deionized water.
[0045] Phosphoric acid solution: prepare 0.01-1.0 molar phosphoric acid solution with deionized water.
[0046] Biologically active substance solution: prepare 10% human growth hormone solution according to the ratio of every 100ml of phosphate buffer + 10mg of human growth hormone.
[0047] The active substance solution of the traditional Chinese medicine: the complex active substance solution of the traditional Chinese medicine is prepared according to every 100ml of normal saline + 10mg of flavonoids and saponins.
[0048] The pH value is 7.0, and 0.01 molar phosphate buffer solution can be purchas
Embodiment 2
[0061] This example prepares the HSV-2 inorganic salt nanoparticle vaccine containing the crude extract of the traditional Chinese medicine Astragalus membranaceus according to the method and steps of Example 1. The difference between it and Example 1 is that the active substance of the selected Chinese medicine complex is: the traditional Chinese medicine Astragalus membranaceus Crude extract, the selected bioactive substance is: HSV-2 protein.
[0062]The host's resistance to many disease viruses mainly depends on the local immune function, especially the immune system of the female vagina, which plays a major role in resisting the invasion of disease pathogens. Therefore, in the immunization and treatment of diseases, the vaginal immunization route and the vaginal administration route have become the focus of research. We synthesized the complex of inorganic salt nanoparticles and the crude extract of traditional Chinese medicine Astragali according to the method of Example 1,
Embodiment 3
[0065] Example 3, Comparative Experiment of Inorganic Salt Nanoparticles Containing Traditional Chinese Medicine Astragalus Polysaccharide as Vaginal Chlamydia Protein Antigen Intramuscular Injection Immunization
[0066] According to the method and steps of Example 1, the Chlamydia vaginalis inorganic salt nanoparticle vaccine containing the active substance of the traditional Chinese medicine astragalus polysaccharide is prepared according to the method and steps of the present example. The difference between it and Example 1 is that the monomer active substance of the selected traditional Chinese medicine is: the traditional Chinese medicine astragalus polysaccharide Active substance, the selected bioactive substance is: Chlamydia vaginalis protein (MOMP).
[0067] We clinically selected 25 patients with vaginal chlamydia, divided them into 5 groups, and used the following drugs: 1. blank; 2. traditional Chinese medicine astragalus polysaccharide; 3. vaginal chlamydia protein (
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