The invention discloses a millivolt-level program-control adjustable voltage output device. The millivolt-level program-control adjustable voltage output device comprises a PC (personal computer), a USB (Universal Serial Bus) data line, a single chip microcomputer programming interface, a selection controller, a voltage boosting controller, an LDO (Low Drop Out) chip, a variable resistor, an inductor, a two-way diode, a voltage output interface and a single chip microcomputer, wherein the single chip microcomputer is connected on the PC by the USB data line, and is connected with the single chip microcomputer programming interface, the selection controller, the voltage boosting controller, the LDO chip, the variable resistor, the inductor, the two-way diode and the voltage output interface. According to the millivolt-level program-control adjustable voltage output device disclosed by the invention, the output accuracy is coordinated, and the manual voltage adjustment is changed into program-control voltage adjustment, so that the adjustment process is stable and reliable; the output of 10000 types of different voltages can be realized by using a single chip microcomputer control technology, so that the use function aspect is greatly expanded; and due to adoption of a self-adaptive voltage adjustment technology, the whole working efficiency is improved to a greater extent. The millivolt-level program-control adjustable voltage output device disclosed by the invention has the advantages of high output accuracy, low noise, low cost, convenience in carry, higher efficiency and convenience in operation and the like.