5 results about "Nephropathy" patented technology

The invention provides an application of umbilical cord mesenchymal stem cells combined with a traditional Chinese medicine extract for preparing a medicine for treating hyperglycemia and diabetic nephropathy. In the application, the umbilical cord mesenchymal stem cells with the differentiative capacity and the potential for treating diabetes are combined with the traditional Chinese medicine extract capable of reducing blood glucose and improving a kidney state and with the inhibitory effect to kidney diseases caused by the diabetes, so that the medicine for treating the hyperglycemia and the diabetic nephropathy is prepared, thereby the blood glucose can be effectively controlled, and the kidney function is improved.

The invention relates to a medicament for treating kidney diseases and a preparation method thereof, and belongs to the field of Chinese medicaments. The medicament is characterized by being prepared from the following raw materials serving as active ingredients in part by weight: 30 to 50 parts of astragalus, 30 to 50 parts of motherwort, 10 to 30 parts of lalang grass rhizome, 10 to 30 parts of polygonum aviculare, 10 to 30 parts of dianthus superbus, 10 to 30 parts of field thistle, 5 to 15 parts of pyrrosia leaf, 5 to 15 parts of garden burnet charcoal, 10 to 30 parts of dock root, and 2 to 4 parts of liquorice. The preparation method comprises the following steps of: (1) performing water extraction and alcohol precipitation on the astragalus, and filtering the extract by using a macroporous resin column to obtain an astragalus extract; (2) adding water or alcohol-water solvent into the motherwort and extracting, and filtering the extract by using an ion exchange resin column to obtain a motherwort extract; (3) adding water or alcohol-water solvent into the dock root and extracting, filtering the extract by using a macroporous adsorption resin or polyamide resin column to obtain a dock root extract; (4) performing water extraction and alcohol precipitation on the field thistle, the lalang grass rhizome, the polygonum aviculare, the dianthus superbus, the pyrrosia leaf, the garden burnet charcoal and the liquorice, to obtain seven extracts; and (5) mixing the four extracts obtained by the steps uniformly to obtain medicinal active substances. The medicinal active substances are used as medicinal effective ingredients and prepared into a preparation by using the conventional technology of pharmaceutics.

The invention relates to activators of FXR useful in the treatment of autoimmune disorders, liver disease, intestinal disease, kidney disease, cancer, and other diseases in which FXR plays a role, having the Formula (I): wherein L₁, A, X₁, X₂, Y₁, Y₂, Y₃, Y₄, R¹, R², and R³ are described herein.

The present disclosure describes peptide inhibitors of Rho-associtated-kinase (ROCK) and their use in treating disorders including heart failure, the leading cause of combined morbidity and mortality in the United States. An inhibitory polypeptide blocks ROCK1 activity in the presence of 1 mM ATP. The binding epitope on ROCK1 was mapped using chemical cross-linking to the Activation Loop, a novel locus identifying a new class of inhibitory drugs. The peptides described will be useful against a number of important diseases such as heart disease, pulmonary hypertension, arterial hypertension, gluacoma management, insulin resistance, kidney disease, hemolytic anemia, stroke, ischemia reperfusion injury, or acute mycloid leukemia.